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Cd81 Gene Detail
Summary
  • Symbol
    Cd81
  • Name
    CD81 antigen
  • Synonyms
    Tapa-1, Tapa1, Tspan28
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096398
    NCBI Gene: 12520
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:142606487-142621667 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 88.10 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    340 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096398
 protein coding gene Chr7:142606476-142621671 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033268
 protein coding gene Chr7:148333614-148348810 (+)
A/J MGP_AJ_G0033251
 protein coding gene Chr7:144034853-144050049 (+)
AKR/J MGP_AKRJ_G0033182
 protein coding gene Chr7:148080009-148100398 (+)
BALB/cJ MGP_BALBcJ_G0033251
 protein coding gene Chr7:143810932-143826261 (+)
C3H/HeJ MGP_C3HHeJ_G0032967
 protein coding gene Chr7:147847858-147863056 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033761
 protein coding gene Chr7:153697398-153712595 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030734
 protein coding gene Chr7:145246724-145263339 (+)
CAST/EiJ MGP_CASTEiJ_G0032289
 protein coding gene Chr7:140149429-140166432 (+)
CBA/J MGP_CBAJ_G0032938
 protein coding gene Chr7:158957014-158972256 (+)
DBA/2J MGP_DBA2J_G0033092
 protein coding gene Chr7:142009185-142024364 (+)
FVB/NJ MGP_FVBNJ_G0033040
 protein coding gene Chr7:141929796-141944986 (+)
LP/J MGP_LPJ_G0033184
 protein coding gene Chr7:149852460-149867648 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033074
 protein coding gene Chr7:159552380-159567574 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033781
 protein coding gene Chr7:147048531-147063723 (+)
PWK/PhJ MGP_PWKPhJ_G0031998
 protein coding gene Chr7:135310931-135327015 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031844
 protein coding gene Chr7:133853849-133869617 (+)
WSB/EiJ MGP_WSBEiJ_G0032401
 protein coding gene Chr7:148049041-148064265 (+)



Homology
more
  • Human Ortholog
    CD81, CD81 molecule
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD81, CD81 molecule
  • Synonyms
    CVID6, S5.7, TAPA1, TSPAN28
  • Links
    NCBI Gene ID: 975
    neXtProt AC: NX_P60033
    UniProt: P60033

  • Chr Location
    11p15.5; chr11:2376177-2397802 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CD81 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 3 alleles in 7 genetic backgrounds
    7 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit altered antibody responses to specific antigens, reductions in peritoneal B-1 cell numbers and IL4 production, increased plasma IgA and IgM levels, and enlarged brains with more astrocytes and microglia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    963
  • Tissues
    135
  • cDNA Data
    349
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12520 NCBI Gene Model | MGI Sequence Detail 15181 C57BL/6J ±  kb
    transcript NM_133655 RefSeq | MGI Sequence Detail 1534 ZRU/MplStud  
    polypeptide P35762 UniProt | EBI | MGI Sequence Detail 236 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 382
      Genomic 24
      cDNA 350
      Primer pair 5
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14716, MGD-MRK-14717, MGI:98485
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 22
      Gene Ontology 16
      Phenotypes 42
    • Earliest
      J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
    • Latest
      J:347576 Abe I, et al., Lipolysis-derived linoleic acid drives beige fat progenitor cell proliferation. Dev Cell. 2022 Dec 5;57(23):2623-2637.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory