Calu MGI Mouse Gene Detail - MGI:1097158

Symbol

Calu
Name

calumenin
Synonyms

9530075H20Rik

Feature Type

protein coding gene
IDs

MGI:1097158
NCBI Gene: 12321
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr6:29348105-29376674 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 12.36 cM
Mapping Data

4 experiments

SNPs within 2kb

706 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1097158	protein coding gene	Chr6:29348068-29377109 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030520	protein coding gene	Chr6:27135635-27166421 (+)
A/J	MGP_AJ_G0030493	protein coding gene	Chr6:25989032-26018076 (+)
AKR/J	MGP_AKRJ_G0030420	protein coding gene	Chr6:26847625-26877829 (+)
BALB/cJ	MGP_BALBcJ_G0030503	protein coding gene	Chr6:26144580-26173474 (+)
C3H/HeJ	MGP_C3HHeJ_G0030216	protein coding gene	Chr6:26845743-26874673 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030957	protein coding gene	Chr6:27921977-27951958 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028168	protein coding gene	Chr6:24196562-24225324 (+)
CAST/EiJ	MGP_CASTEiJ_G0029618	protein coding gene	Chr6:26642682-26674697 (+)
CBA/J	MGP_CBAJ_G0030194	protein coding gene	Chr6:28963455-28995686 (+)
DBA/2J	MGP_DBA2J_G0030338	protein coding gene	Chr6:25931247-25960431 (+)
FVB/NJ	MGP_FVBNJ_G0030292	protein coding gene	Chr6:25687274-25716721 (+)
LP/J	MGP_LPJ_G0030425	protein coding gene	Chr6:27269731-27300794 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030328	protein coding gene	Chr6:31481875-31513965 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030987	protein coding gene	Chr6:26721165-26752744 (+)
PWK/PhJ	MGP_PWKPhJ_G0029332	protein coding gene	Chr6:25467158-25496922 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029168	protein coding gene	Chr6:26441082-26469793 (+)
WSB/EiJ	MGP_WSBEiJ_G0029694	protein coding gene	Chr6:26695177-26724779 (+)

Human Ortholog

CALU, calumenin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CALU, calumenin
Links

HGNC:1458

NCBI Gene ID: 813

neXtProt AC: NX_O43852

UniProt: O43852
Chr Location

7q32.1; chr7:128739292-128773400 (+) GRCh38

MGI Vertebrate Homology

Calu stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CALU
Gene Tree

Calu

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Endonuclease-mediated

5
Gene trapped

13
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

927
Tissues

121
cDNA Data

443
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase calu

ZFIN calua, calub

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All Sequences

83
RefSeq

8
UniProt

14
CCDS

CCDS19957.1, CCDS19958.1

Ensembl

ENSMUSG00000029767 (Evidence)
NCBI Gene

12321

			Length	Strain/Species	Flank
genomic	12321	NCBI Gene Model \| MGI Sequence Detail	28570	C57BL/6J	± kb
transcript	NM_184053	RefSeq \| MGI Sequence Detail	3229	C57BL/6
polypeptide	O35887	UniProt \| EBI \| MGI Sequence Detail	315	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000004986 calumenin

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair
GlyGen

O35887 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 449

cDNA 444

Primer pair 4

Other 1

Microarray probesets 4

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MGI:2442053

Summaries

All 45

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 11
Earliest

J:154091 Gogstad GO, et al., Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Biochim Biophys Acta. 1981 Sep 29;670(2):150-62
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Calu:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55240	Chr6:29348113-29348122 (+)	13 bp
Tssr55241	Chr6:29348135-29348141 (+)	33 bp
Tssr55242	Chr6:29348142-29348158 (+)	45 bp
Tssr55243	Chr6:29348162-29348164 (+)	58 bp
Tssr55244	Chr6:29348174-29348183 (+)	74 bp
Tssr55245	Chr6:29361409-29361424 (+)	13,312 bp
Tssr55246	Chr6:29366116-29366133 (+)	18,020 bp
Tssr55247	Chr6:29374476-29374479 (+)	26,373 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24