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Neo1 Gene Detail
Summary
  • Symbol
    Neo1
  • Name
    neogenin
  • Synonyms
    2610028H22Rik, D930014N22Rik, Igdcc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097159
    NCBI Gene: 18007
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:58781970-58943724 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.81 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3687 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097159
 protein coding gene Chr9:58781962-58943926 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034896
 protein coding gene Chr9:58181095-58342094 (-)
A/J MGP_AJ_G0034877
 protein coding gene Chr9:56294664-56458636 (-)
AKR/J MGP_AKRJ_G0034806
 protein coding gene Chr9:57595254-57759781 (-)
BALB/cJ MGP_BALBcJ_G0034869
 protein coding gene Chr9:56063731-56226713 (-)
C3H/HeJ MGP_C3HHeJ_G0034579
 protein coding gene Chr9:58091693-58270847 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035388
 protein coding gene Chr9:59801423-59972091 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032299
 protein coding gene Chr9:55564276-55722422 (-)
CAST/EiJ MGP_CASTEiJ_G0033900
 protein coding gene Chr9:58177986-58346934 (-)
CBA/J MGP_CBAJ_G0034550
 protein coding gene Chr9:61890209-62058393 (-)
DBA/2J MGP_DBA2J_G0034709
 protein coding gene Chr9:56142034-56302774 (-)
FVB/NJ MGP_FVBNJ_G0034651
 protein coding gene Chr9:55386120-55551240 (-)
LP/J MGP_LPJ_G0034792
 protein coding gene Chr9:58463714-58633933 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034694
 protein coding gene Chr9:63328930-63532168 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035410
 protein coding gene Chr9:57609886-57770248 (-)
PWK/PhJ MGP_PWKPhJ_G0033604
 protein coding gene Chr9:56204756-56371279 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033439
 protein coding gene Chr9:57890227-58065439 (-)
WSB/EiJ MGP_WSBEiJ_G0034013
 protein coding gene Chr9:57561382-57724800 (-)



Homology
more
  • Human Ortholog
    NEO1, neogenin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEO1, neogenin 1
  • Synonyms
    IGDCC2, NGN, NTN1R2
  • Links
    NCBI Gene ID: 4756
    neXtProt AC: NX_Q92859
    UniProt: Q92859

  • Chr Location
    15q24.1; chr15:73051692-73305206 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele display perinatal lethality and abnormal trigeminal nerve development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1632
  • Tissues
    458
  • cDNA Data
    177
  • Literature Summary
    58
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032340 Ensembl Gene Model | MGI Sequence Detail 161755 C57BL/6J ±  kb
    transcript ENSMUST00000068664 Ensembl | MGI Sequence Detail 7379 Not Applicable  
    polypeptide ENSMUSP00000063656 Ensembl | MGI Sequence Detail 1492 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 195
      cDNA 182
      Primer pair 10
      Other 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1925636, MGI:2143026, MGI:2444534
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 58
      Gene Ontology 13
      Phenotypes 41
    • Earliest
      J:42348 Keeling SL, et al., Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis. Oncogene. 1997 Aug 7;15(6):691-700
    • Latest
      J:349512 Wang XF, et al., The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity. Nat Commun. 2024 Feb 3;15(1):1037
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory