Tcl1 MGI Mouse Gene Detail - MGI:1097166 - T cell lymphoma breakpoint 1

Symbol

Tcl1
Name

T cell lymphoma breakpoint 1

Feature Type

protein coding gene
IDs

MGI:1097166
NCBI Gene: 21432
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:105183012-105188996 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 55.28 cM
Mapping Data

4 experiments

SNPs within 2kb

294 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1097166	protein coding gene	Chr12:105183009-105189052 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020089	protein coding gene	Chr12:107079623-107085666 (-)
A/J	MGP_AJ_G0020043	protein coding gene	Chr12:103073064-103079107 (-)
AKR/J	MGP_AKRJ_G0020019	protein coding gene	Chr12:106060468-106066511 (-)
BALB/cJ	MGP_BALBcJ_G0020029	protein coding gene	Chr12:103493325-103499369 (-)
C3H/HeJ	MGP_C3HHeJ_G0019831	protein coding gene	Chr12:106497484-106503527 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020474	protein coding gene	Chr12:110400920-110406963 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018086	protein coding gene	Chr12:99688246-99694834 (-)
CAST/EiJ	MGP_CASTEiJ_G0019373	protein coding gene	Chr12:101287048-101293061 (-)
CBA/J	MGP_CBAJ_G0019798	protein coding gene	Chr12:114742853-114748896 (-)
DBA/2J	MGP_DBA2J_G0019915	protein coding gene	Chr12:102611643-102617686 (-)
FVB/NJ	MGP_FVBNJ_G0019900	protein coding gene	Chr12:101376948-101382992 (-)
LP/J	MGP_LPJ_G0019990	protein coding gene	Chr12:106966442-106972485 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019938	protein coding gene	Chr12:118149932-118155975 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020503	protein coding gene	Chr12:105443567-105449611 (-)
PWK/PhJ	MGP_PWKPhJ_G0019132	protein coding gene	Chr12:97187638-97193330 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018936	protein coding gene	Chr12:99693356-99701142 (-)
WSB/EiJ	MGP_WSBEiJ_G0019430	protein coding gene	Chr12:106414863-106420909 (-)

Human Ortholog

TCL1A, TCL1 family AKT coactivator A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TCL1A, TCL1 family AKT coactivator A
Synonyms

TCL1
Links

HGNC:11648

NCBI Gene ID: 8115

neXtProt AC: NX_P56279

UniProt: P56279
Chr Location

14q32.13; chr14:95709947-95714196 (-) GRCh38

MGI Vertebrate Homology

Tcl1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TCL1A
Gene Tree

Tcl1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

3
Targeted

2
Genomic Mutations

1 involving Tcl1
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display a maternal fertility defect that leads to a progressive reduction in litter size and a shortened reproductive lifespan. Reduced female fertility is caused by impaired blastomere proliferation in the early preimplantation embryo.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

792
Tissues

25
cDNA Data

93
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

63
RefSeq

9
UniProt

5
CCDS

CCDS36549.1, CCDS70418.1, CCDS83999.1

Ensembl

ENSMUSG00000041359 (Evidence)
NCBI Gene

21432

			Length	Strain/Species	Flank
genomic	21432	NCBI Gene Model \| MGI Sequence Detail	5985	C57BL/6J	± kb
transcript	NR_110339	RefSeq \| MGI Sequence Detail	1656	ZRU/MplStud
polypeptide	P56280	UniProt \| EBI \| MGI Sequence Detail	116	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016193 T-cell leukemia/lymphoma protein 1A

(term hierarchy)
PDB

1JNP
InterPro Domains

IPR004832 TCL1/MTCP1

IPR036672 TCL1/MTCP1 superfamily

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All nucleic 98

Genomic 2

cDNA 93

Primer pair 3

Microarray probesets 3

Summaries

All 62

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 15
Earliest

J:42464 Narducci MG, et al., The murine Tcl1 oncogene: embryonic and lymphoid cell expression. Oncogene. 1997 Aug 18;15(8):919-26
Latest

J:335502 Stachelscheid J, et al., The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL. Blood. 2023 Mar 23;141(12):1425-1441

TSS for Tcl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117604	Chr12:105189020-105189031 (-)	-30 bp
Tssr117603	Chr12:105188993-105189004 (-)	-3 bp
Tssr117602	Chr12:105188971-105188981 (-)	20 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24