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Ogg1 Gene Detail
Summary
  • Symbol
    Ogg1
  • Name
    8-oxoguanine DNA-glycosylase 1
  • Synonyms
    Mmh
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097693
    NCBI Gene: 18294
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113303959-113311149 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.75 cM, cytoband E-F1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    258 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097693
 protein coding gene Chr6:113303933-113312029 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031117
 protein coding gene Chr6:115835377-115847890 (+)
A/J MGP_AJ_G0031086
 protein coding gene Chr6:111399857-111407882 (+)
AKR/J MGP_AKRJ_G0031017
 protein coding gene Chr6:114391397-114399436 (+)
BALB/cJ MGP_BALBcJ_G0031097
 protein coding gene Chr6:111349013-111357026 (+)
C3H/HeJ MGP_C3HHeJ_G0030611
 protein coding gene Chr6:69895057-69902733 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031556
 protein coding gene Chr6:118838153-118847797 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028720
 protein coding gene Chr6:108407365-108415100 (+)
CAST/EiJ MGP_CASTEiJ_G0030204
 protein coding gene Chr6:114824351-114834433 (+)
CBA/J MGP_CBAJ_G0030783
 protein coding gene Chr6:123532981-123543626 (+)
DBA/2J MGP_DBA2J_G0030936
 protein coding gene Chr6:110482920-110491572 (+)
FVB/NJ MGP_FVBNJ_G0030890
 protein coding gene Chr6:109482011-109490300 (+)
LP/J MGP_LPJ_G0031016
 protein coding gene Chr6:115880670-115888668 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030924
 protein coding gene Chr6:127797988-127806729 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031583
 protein coding gene Chr6:114406185-114415066 (+)
PWK/PhJ MGP_PWKPhJ_G0029920
 protein coding gene Chr6:109433299-109441751 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029748
 protein coding gene Chr6:113223881-113233224 (+)
WSB/EiJ MGP_WSBEiJ_G0030288
 protein coding gene Chr6:114779579-114787437 (+)



Homology
more
  • Human Ortholog
    OGG1, 8-oxoguanine DNA glycosylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OGG1, 8-oxoguanine DNA glycosylase
  • Synonyms
    HMMH, HOGG1, MUTM, OGH1
  • Links
    NCBI Gene ID: 4968
    neXtProt AC: NX_O15527
    UniProt: O15527

  • Chr Location
    3p25.3; chr3:9749944-9788219 (+)  GRCh38
Human Diseases
more
  • Diseases
    16 with human OGG1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 4 genetic backgrounds
    17 phenotypes from multigenic genotypes
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to accumulation of 8-hydroxyguanine and altered DNA repair. Mice homozygous for a knock-out allele remain healthy until at least 18 months of age. Mice homozygous for another knock-out allele develop spontaneouslung adenoma/carcinoma at ~1.5 years of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    2
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18294 NCBI Gene Model | MGI Sequence Detail 7191 C57BL/6J ±  kb
    transcript NR_149720 RefSeq | MGI Sequence Detail 1606 ZRU/MplStud  
    polypeptide O08760 UniProt | EBI | MGI Sequence Detail 345 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 18
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 3
      Gene Ontology 20
      Phenotypes 80
    • Earliest
      J:28683 Takeda T, et al., A new murine model of accelerated senescence. Mech Ageing Dev. 1981 Oct;17(2):183-94
    • Latest
      J:343650 Song C, et al., OGG1 promoted lung fibrosis by activating fibroblasts via interacting with Snail1. Int Immunopharmacol. 2023 Nov 15;126:111148
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory