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Cenpe Gene Detail
Summary
  • Symbol
    Cenpe
  • Name
    centromere protein E
  • Synonyms
    312kDa, CENP-E, Kif10, N-7 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098230
    NCBI Gene: 229841
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:134918324-134979301 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 62.55 cM, cytoband H2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1995 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098230
 protein coding gene Chr3:134918298-134979372 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027902
 protein coding gene Chr3:138074792-138139585 (+)
A/J MGP_AJ_G0027860
 protein coding gene Chr3:133231500-133294200 (+)
AKR/J MGP_AKRJ_G0027825
 protein coding gene Chr3:136764102-136823800 (+)
BALB/cJ MGP_BALBcJ_G0027873
 protein coding gene Chr3:133093340-133152992 (+)
C3H/HeJ MGP_C3HHeJ_G0027602
 protein coding gene Chr3:137101592-137164751 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028316
 protein coding gene Chr3:142919053-142982512 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025654
 protein coding gene Chr3:128476545-128539127 (+)
CAST/EiJ MGP_CASTEiJ_G0027058
 protein coding gene Chr3:136832510-136894644 (+)
CBA/J MGP_CBAJ_G0027578
 protein coding gene Chr3:147753086-147822713 (+)
DBA/2J MGP_DBA2J_G0027718
 protein coding gene Chr3:132400709-132461743 (+)
FVB/NJ MGP_FVBNJ_G0027685
 protein coding gene Chr3:129890931-129952167 (+)
LP/J MGP_LPJ_G0027828
 protein coding gene Chr3:139507476-139583527 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027716
 protein coding gene Chr3:155874254-155944468 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028374
 protein coding gene Chr3:136299205-136364587 (+)
PWK/PhJ MGP_PWKPhJ_G0026782
 protein coding gene Chr3:132109384-132173296 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026608
 protein coding gene Chr3:134377921-134443181 (+)
WSB/EiJ MGP_WSBEiJ_G0027137
 protein coding gene Chr3:137088285-137151315 (+)



Homology
more
  • Human Ortholog
    CENPE, centromere protein E
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CENPE, centromere protein E
  • Synonyms
    CENP-E, KIF10, MCPH13, PPP1R61
  • Links
    NCBI Gene ID: 1062
    neXtProt AC: NX_Q02224
    UniProt: Q02224

  • Chr Location
    4q24; chr4:103105349-103198445 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CENPE associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display early embryonic lethality. Mutant embryos grown in culture exhibit inner cell mass growth defects and mitotic chromosome misalignment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    134
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 229841 NCBI Gene Model | MGI Sequence Detail 60978 C57BL/6J ±  kb
    transcript NM_173762 RefSeq | MGI Sequence Detail 7813 ZRU/MplStud  
    polypeptide Q6RT24 UniProt | EBI | MGI Sequence Detail 2474 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      cDNA 134

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1941, MGI:2677846, MGI:3034640, MGI:88377
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 14
      Phenotypes 18
    • Earliest
      J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory