Nrg2 MGI Mouse Gene Detail - MGI:1098246

Symbol

Nrg2
Name

neuregulin 2
Synonyms

Don1, NTAK

Feature Type

protein coding gene
IDs

MGI:1098246
NCBI Gene: 100042150
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr18:36150705-36330433 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.38 cM
Mapping Data

1 experiment

SNPs within 2kb

3761 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098246	protein coding gene	Chr18:36147634-36332754 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024274	protein coding gene	Chr18:34381927-34575508 (-)
A/J	MGP_AJ_G0024240	protein coding gene	Chr18:33182428-33367590 (-)
AKR/J	MGP_AKRJ_G0024208	protein coding gene	Chr18:34107055-34289398 (-)
BALB/cJ	MGP_BALBcJ_G0024240	protein coding gene	Chr18:33230356-33414560 (-)
C3H/HeJ	MGP_C3HHeJ_G0024007	protein coding gene	Chr18:34164042-34354038 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024681	protein coding gene	Chr18:35608236-35798444 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022121	protein coding gene	Chr18:33281100-33462131 (-)
CAST/EiJ	MGP_CASTEiJ_G0023482	protein coding gene	Chr18:34151520-34350457 (-)
CBA/J	MGP_CBAJ_G0023975	protein coding gene	Chr18:36638900-36845569 (-)
DBA/2J	MGP_DBA2J_G0024107	protein coding gene	Chr18:32812739-32995676 (-)
FVB/NJ	MGP_FVBNJ_G0024074	protein coding gene	Chr18:32511958-32693878 (-)
LP/J	MGP_LPJ_G0024189	protein coding gene	Chr18:34414580-34608200 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024102	protein coding gene	Chr18:37865539-38058022 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024730	protein coding gene	Chr18:33969482-34158889 (-)
PWK/PhJ	MGP_PWKPhJ_G0023226	protein coding gene	Chr18:33045869-33231661 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023033	protein coding gene	Chr18:34227899-34420202 (-)
WSB/EiJ	MGP_WSBEiJ_G0023545	protein coding gene	Chr18:33888528-34083024 (-)

Human Ortholog

NRG2, neuregulin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NRG2, neuregulin 2
Synonyms

DON1, HRG2, NTAK
Links

HGNC:7998

NCBI Gene ID: 9542

neXtProt AC: NX_O14511

UniProt: O14511
Chr Location

5q31.2; chr5:139846779-140043299 (-) GRCh38

MGI Vertebrate Homology

Nrg2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NRG2
Gene Tree

Nrg2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

4
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

About one third of mice homozygous for a knock-out allele die prior to weaning in the absence of cardiac defects or other morphological abnormalities. Homozygotes display an early but transient postnatal growth deficit and reduced reproductive capacity.

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All GO Annotations

29
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

762
Tissues

39
cDNA Data

21
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN nrg2a, nrg2b

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All Sequences

67
RefSeq

22
UniProt

8
CCDS

CCDS50255.1

Ensembl

ENSMUSG00000060275 (Evidence)
NCBI Gene

100042150

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060275	Ensembl Gene Model \| MGI Sequence Detail	179729	C57BL/6J	± kb
transcript	ENSMUST00000115713	Ensembl \| MGI Sequence Detail	3056	Not Applicable
polypeptide	ENSMUSP00000111378	Ensembl \| MGI Sequence Detail	857	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000011423 pro-neuregulin-2, membrane-bound isoform

(term hierarchy)
InterPro Domains

IPR000742 EGF-like domain

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR040180 Neuregulin

IPR002154 Neuregulin, C-terminal
GlyGen

P56974 4 sites, 4 N-linked glycans (3 sites)

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All nucleic 25

Genomic 1

cDNA 21

Primer pair 2

Other 1

Microarray probesets 3

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MGI:894700

Summaries

All 42

Developmental Gene Expression 9

Gene Ontology 10

Phenotypes 6
Earliest

J:41106 Busfield SJ, et al., Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus. Mol Cell Biol. 1997 Jul;17(7):4007-14
Latest

J:334091 Zhang X, et al., Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain. iScience. 2023 Mar 17;26(3):106242

TSS for Nrg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152927	Chr18:36330396-36330456 (-)	7 bp
Tssr152926	Chr18:36330368-36330382 (-)	58 bp
Tssr152925	Chr18:36259396-36259398 (-)	71,036 bp
Tssr152924	Chr18:36236240-36236242 (-)	94,192 bp
Tssr152923	Chr18:36201664-36201674 (-)	128,764 bp
Tssr152922	Chr18:36200683-36200688 (-)	129,747 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24