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Psmb4 Gene Detail
Summary
  • Symbol
    Psmb4
  • Name
    proteasome (prosome, macropain) subunit, beta type 4
  • Synonyms
    Pros-27
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098257
    NCBI Gene: 19172
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:94791635-94794269 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.74 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098257
 protein coding gene Chr3:94791404-94794272 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027561
 protein coding gene Chr3:95555150-95558018 (-)
A/J MGP_AJ_G0027518
 protein coding gene Chr3:92606386-92609254 (-)
AKR/J MGP_AKRJ_G0027487
 protein coding gene Chr3:94723178-94726047 (-)
BALB/cJ MGP_BALBcJ_G0027532
 protein coding gene Chr3:92342404-92345273 (-)
C3H/HeJ MGP_C3HHeJ_G0027265
 protein coding gene Chr3:95002639-95005507 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027979
 protein coding gene Chr3:99103392-99106260 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025320
 protein coding gene Chr3:88968237-88971171 (-)
CAST/EiJ MGP_CASTEiJ_G0026713
 protein coding gene Chr3:94303841-94306714 (-)
CBA/J MGP_CBAJ_G0027241
 protein coding gene Chr3:102670446-102673314 (-)
DBA/2J MGP_DBA2J_G0027379
 protein coding gene Chr3:91887506-91890375 (-)
FVB/NJ MGP_FVBNJ_G0027352
 protein coding gene Chr3:89974360-89977229 (-)
LP/J MGP_LPJ_G0027490
 protein coding gene Chr3:96824887-96827755 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027379
 protein coding gene Chr3:108841148-108844020 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028034
 protein coding gene Chr3:94395554-94398423 (-)
PWK/PhJ MGP_PWKPhJ_G0026443
 protein coding gene Chr3:91783975-91786848 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026262
 protein coding gene Chr3:92659005-92661870 (-)
WSB/EiJ MGP_WSBEiJ_G0026795
 protein coding gene Chr3:94769630-94772499 (-)



Homology
more
  • Human Ortholog
    PSMB4, proteasome 20S subunit beta 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMB4, proteasome 20S subunit beta 4
  • Synonyms
    HN3, HsN3, PRAAS3, PROS-26, PROS26
  • Links
    NCBI Gene ID: 5692
    neXtProt AC: NX_P28070
    UniProt: P28070

  • Chr Location
    1q21.3; chr1:151399560-151401937 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PSMB4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    341
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 19172 NCBI Gene Model | MGI Sequence Detail 2635 C57BL/6J ±  kb
transcript NM_008945 RefSeq | MGI Sequence Detail 949 C57BL/6  
polypeptide P99026 UniProt | EBI | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 341
    cDNA 341

    Microarray probesets 6
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:40825 Cruz M, et al., Cloning and characterization of mouse Lmp3 cDNA, encoding a proteasome beta subunit. Gene. 1997 May 6;190(2):251-6
  • Latest
    J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory