Kif13b MGI Mouse Gene Detail - MGI:1098265

Symbol

Kif13b
Name

kinesin family member 13B
Synonyms

5330429L19Rik, C130021D12Rik, GAKIN, N-3 kinesin

Feature Type

protein coding gene
IDs

MGI:1098265
NCBI Gene: 16554
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:64889633-65047067 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 33.77 cM, cytoband C3
Mapping Data

3 experiments

SNPs within 2kb

3181 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098265	protein coding gene	Chr14:64884714-65047067 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021473	protein coding gene	Chr14:59223245-59388296 (+)
A/J	MGP_AJ_G0021432	protein coding gene	Chr14:57865198-58026124 (+)
AKR/J	MGP_AKRJ_G0021408	protein coding gene	Chr14:59893090-60053294 (+)
BALB/cJ	MGP_BALBcJ_G0021438	protein coding gene	Chr14:57813631-57972764 (+)
C3H/HeJ	MGP_C3HHeJ_G0021215	protein coding gene	Chr14:59533660-59700191 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021877	protein coding gene	Chr14:61993394-62165667 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019417	protein coding gene	Chr14:55804769-55961142 (+)
CAST/EiJ	MGP_CASTEiJ_G0020732	protein coding gene	Chr14:56018361-56181309 (+)
CBA/J	MGP_CBAJ_G0021182	protein coding gene	Chr14:63858031-64029075 (+)
DBA/2J	MGP_DBA2J_G0021305	protein coding gene	Chr14:57528140-57685699 (+)
FVB/NJ	MGP_FVBNJ_G0021284	protein coding gene	Chr14:56925752-57083993 (+)
LP/J	MGP_LPJ_G0021380	protein coding gene	Chr14:60257952-60421916 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021313	protein coding gene	Chr14:63012975-63179464 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021900	protein coding gene	Chr14:59059031-59224310 (+)
PWK/PhJ	MGP_PWKPhJ_G0020476	protein coding gene	Chr14:54228402-54388151 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020309	protein coding gene	Chr14:55030336-55194996 (+)
WSB/EiJ	MGP_WSBEiJ_G0020785	protein coding gene	Chr14:59380033-59542701 (+)

Human Ortholog

KIF13B, kinesin family member 13B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF13B, kinesin family member 13B
Synonyms

GAKIN
Links

HGNC:14405

NCBI Gene ID: 23303

neXtProt AC: NX_Q9NQT8

UniProt: Q9NQT8
Chr Location

8p12; chr8:29067278-29263388 (-) GRCh38

MGI Vertebrate Homology

Kif13b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KIF13B
Gene Tree

Kif13b

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Phenotype Summary

7 phenotypes from 3 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

53
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

42
Targeted

8
Genomic Mutations

1 involving Kif13b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

109 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased circulating cholesterol and factor VIII levels.

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All GO Annotations

15
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

4
cDNA Data

38
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kif13b

ZFIN kif13bb

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All Sequences

55
RefSeq

10
UniProt

5
CCDS

CCDS36954.1

Ensembl

ENSMUSG00000060012 (Evidence)
NCBI Gene

16554

			Length	Strain/Species	Flank
genomic	16554	NCBI Gene Model \| MGI Sequence Detail	157435	C57BL/6J	± kb
transcript	NM_001081177	RefSeq \| MGI Sequence Detail	8915	C57BL/6
polypeptide	NP_001074646	RefSeq \| MGI Sequence Detail	1843	C57BL/6

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UniProt

5 Sequences
PDB

5B64
InterPro Domains

IPR000938 CAP Gly-rich domain

IPR036859 CAP Gly-rich domain superfamily

IPR000253 Forkhead-associated (FHA) domain

IPR032405 Kinesin-associated

IPR022164 Kinesin-like

IPR022140 Kinesin-like KIF1-type

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR008984 SMAD/FHA domain superfamily
GlyGen

A0A286YCV9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 41

Genomic 1

cDNA 40

Microarray probesets 6

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MGI:1924355, MGI:2145641

Summaries

All 50

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 21
Earliest

J:42822 Nakagawa T, et al., Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9654-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kif13b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126187	Chr14:64889934-64889943 (+)	306 bp
Tssr126188	Chr14:64889952-64889970 (+)	328 bp
Tssr126189	Chr14:64889973-64890004 (+)	356 bp
Tssr126190	Chr14:64890008-64890031 (+)	387 bp
Tssr126192	Chr14:64928136-64928140 (+)	38,505 bp
Tssr126193	Chr14:64957768-64957772 (+)	68,137 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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