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Ogdh Gene Detail
Summary
  • Symbol
    Ogdh
  • Name
    oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
  • Synonyms
    2210403E04Rik, 2210412K19Rik, alpha-ketoglutarate dehydrogenase, d1401
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098267
    NCBI Gene: 18293
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:6241633-6306642 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 3.94 cM, cytoband A1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1473 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098267
 protein coding gene Chr11:6241597-6309094 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018020
 protein coding gene Chr11:3392710-3462960 (+)
A/J MGP_AJ_G0017993
 protein coding gene Chr11:3256690-3324493 (+)
AKR/J MGP_AKRJ_G0017957
 protein coding gene Chr11:3417590-3486728 (+)
BALB/cJ MGP_BALBcJ_G0017961
 protein coding gene Chr11:3263566-3330867 (+)
C3H/HeJ MGP_C3HHeJ_G0017774
 protein coding gene Chr11:3289653-3356268 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018413
 protein coding gene Chr11:3495594-3565583 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016071
 protein coding gene Chr11:3149084-3213577 (+)
CAST/EiJ MGP_CASTEiJ_G0017336
 protein coding gene Chr11:3269650-3339041 (+)
CBA/J MGP_CBAJ_G0017749
 protein coding gene Chr11:3896136-3971207 (+)
DBA/2J MGP_DBA2J_G0017859
 protein coding gene Chr11:3170518-3238280 (+)
FVB/NJ MGP_FVBNJ_G0017851
 protein coding gene Chr11:3186230-3253987 (+)
LP/J MGP_LPJ_G0017930
 protein coding gene Chr11:3471203-3544494 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017877
 protein coding gene Chr11:3451655-3524495 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018453
 protein coding gene Chr11:3430866-3497692 (+)
PWK/PhJ MGP_PWKPhJ_G0017116
 protein coding gene Chr11:3199099-3266953 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016913
 protein coding gene Chr11:3382984-3449411 (+)
WSB/EiJ MGP_WSBEiJ_G0017390
 protein coding gene Chr11:3264074-3329253 (+)



Homology
more
  • Human Ortholog
    OGDH, oxoglutarate dehydrogenase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OGDH, oxoglutarate dehydrogenase
  • Synonyms
    AKGDH, E1k, E1o, HsOGDH, KGD1, OGDC, OGDH2, OGDHD, OGDH-E1
  • Links
    NCBI Gene ID: 4967
    neXtProt AC: NX_Q02218
    UniProt: Q02218

  • Chr Location
    7p13; chr7:44606572-44709066 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human OGDH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    913
  • Tissues
    142
  • cDNA Data
    23
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020456 Ensembl Gene Model | MGI Sequence Detail 65010 C57BL/6J ±  kb
    transcript ENSMUST00000093350 Ensembl | MGI Sequence Detail 4075 Not Applicable  
    polypeptide ENSMUSP00000091041 Ensembl | MGI Sequence Detail 1034 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000011612 2-oxoglutarate dehydrogenase complex component E1
      (term hierarchy)
    • PDB
      3E2H, 3TF7
    • EC
      1.2.4.2
    • InterPro Domains
      IPR011603 2-oxoglutarate dehydrogenase E1 component
      IPR032106 2-oxoglutarate dehydrogenase E1 component, N-terminal domain
      IPR001017 Dehydrogenase, E1 component
      IPR031717 Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal
      IPR042179 Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily
      IPR029061 Thiamin diphosphate-binding fold
      IPR005475 Transketolase-like, pyrimidine-binding domain
    • GlyGen
      Q60597 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 23
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917392, MGI:1922924, MGI:2143998
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:43415 Udaka K, et al., A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11272-6
    • Latest
      J:346910 Ayyangar U, et al., Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin. EMBO J. 2024 Apr;43(7):1113-1134
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory