Rnasel MGI Mouse Gene Detail - MGI:1098272 - ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)

Symbol

Rnasel
Name

ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
Synonyms

2-5A-dependent RNAase, E230029I04Rik

Feature Type

protein coding gene
IDs

MGI:1098272
NCBI Gene: 24014
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr1:153625172-153639967 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 65.43 cM, cytoband G2
Mapping Data

2 experiments

SNPs within 2kb

488 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098272	protein coding gene	Chr1:153625089-153644441 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016601	protein coding gene	Chr1:158593591-158608842 (+)
A/J	MGP_AJ_G0016583	protein coding gene	Chr1:152201880-152214302 (+)
AKR/J	MGP_AKRJ_G0016548	protein coding gene	Chr1:156911655-156925415 (+)
BALB/cJ	MGP_BALBcJ_G0016543	protein coding gene	Chr1:152749241-152763978 (+)
C3H/HeJ	MGP_C3HHeJ_G0016368	protein coding gene	Chr1:157012319-157028429 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017004	protein coding gene	Chr1:164070239-164082473 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014713	protein coding gene	Chr1:144487535-144503747 (+)
CAST/EiJ	MGP_CASTEiJ_G0015947	protein coding gene	Chr1:156536009-156549709 (+)
CBA/J	MGP_CBAJ_G0016342	protein coding gene	Chr1:169838502-169858880 (+)
DBA/2J	MGP_DBA2J_G0016448	protein coding gene	Chr1:151225446-151238070 (+)
FVB/NJ	MGP_FVBNJ_G0016446	protein coding gene	Chr1:149682930-149694549 (+)
LP/J	MGP_LPJ_G0016519	protein coding gene	Chr1:159717842-159731410 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016472	protein coding gene	Chr1:177462300-177477110 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017040	protein coding gene	Chr1:156691665-156706178 (+)
PWK/PhJ	MGP_PWKPhJ_G0015733	protein coding gene	Chr1:150267288-150278126 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015520	protein coding gene	Chr1:155492021-155507283 (+)
WSB/EiJ	MGP_WSBEiJ_G0016010	protein coding gene	Chr1:156774585-156787533 (+)

Human Ortholog

RNASEL, ribonuclease L

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNASEL, ribonuclease L
Synonyms

PRCA1, RNS4
Links

HGNC:10050

NCBI Gene ID: 6041

neXtProt AC: NX_Q05823

UniProt: Q05823
Chr Location

1q25.3; chr1:182573634-182589256 (-) GRCh38

MGI Vertebrate Homology

Rnasel stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RNASEL
Gene Tree

Rnasel

Diseases

2 with human RNASEL associations

				Human Disease	Mouse Models
				Lynch syndrome IDs Lynch syndrome DOID:3883 DOID:0050586 DOID:3040 MESH:D003123 NCI:C8494 OMIM:PS120435 ORDO:144 UMLS_CUI:C0009405 UMLS_CUI:C4552100
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

2
Endonuclease-mediated

3
Targeted

1
Genomic Mutations

2 involving Rnasel
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene have an enlarged spleen and increased succeptibility to viral infection.

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All GO Annotations

31
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

9
cDNA Data

40
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

75
RefSeq

22
UniProt

8
CCDS

CCDS15377.1

Ensembl

ENSMUSG00000066800 (Evidence)
NCBI Gene

24014

			Length	Strain/Species	Flank
genomic	ENSMUSG00000066800	Ensembl Gene Model \| MGI Sequence Detail	14796	C57BL/6J	± kb
transcript	ENSMUST00000086209	Ensembl \| MGI Sequence Detail	2938	Not Applicable
polypeptide	ENSMUSP00000083385	Ensembl \| MGI Sequence Detail	735	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000014058 2-5A-dependent ribonuclease

(term hierarchy)
EC

3.1.26.-
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR010513 KEN domain

IPR038357 KEN domain superfamily

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR042745 RNase L, RNase domain

IPR045133 Serine/threonine-protein kinase/endoribonuclease IRE1/2-like

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All nucleic 42

Genomic 1

cDNA 41

Microarray probesets 5

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MGI:2445191

Summaries

All 76

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 36
Earliest

J:43378 Zhou A, et al., Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action. Cell. 1993 Mar 12;72(5):753-65
Latest

J:349727 Xi J, et al., Initiation of a ZAKalpha-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L. Cell Rep. 2024 Apr 23;43(4):113998

TSS for Rnasel:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9479	Chr1:153625160-153625188 (+)	2 bp
Tssr9480	Chr1:153625195-153625237 (+)	44 bp
Tssr9481	Chr1:153625242-153625269 (+)	84 bp
Tssr9482	Chr1:153625452-153625492 (+)	300 bp
Tssr9483	Chr1:153627612-153627622 (+)	2,445 bp
Tssr9484	Chr1:153627627-153627653 (+)	2,468 bp
Tssr9485	Chr1:153627692-153627746 (+)	2,547 bp
Tssr9486	Chr1:153627748-153627780 (+)	2,592 bp
Tssr9487	Chr1:153628529-153628548 (+)	3,367 bp
Tssr9488	Chr1:153628556-153628577 (+)	3,395 bp
Tssr9489	Chr1:153628598-153628614 (+)	3,434 bp
Tssr9490	Chr1:153628734-153628737 (+)	3,564 bp
Tssr9491	Chr1:153636655-153636660 (+)	11,486 bp
Tssr9492	Chr1:153636969-153637002 (+)	11,814 bp
Tssr9493	Chr1:153638293-153638320 (+)	13,135 bp
Tssr9494	Chr1:153638327-153638360 (+)	13,172 bp
Tssr9495	Chr1:153638368-153638384 (+)	13,204 bp
Tssr9496	Chr1:153638725-153638731 (+)	13,556 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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