C9 MGI Mouse Gene Detail - MGI:1098282

Symbol

C9
Name

complement component 9

Feature Type

protein coding gene
IDs

MGI:1098282
NCBI Gene: 12279
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:6474808-6528232 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 2.79 cM, cytoband A1
Mapping Data

1 experiment

SNPs within 2kb

1308 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098282	protein coding gene	Chr15:6474808-6528306 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021696	protein coding gene	Chr15:3414586-3473123 (+)
A/J	MGP_AJ_G0021657	protein coding gene	Chr15:3365677-3420358 (+)
AKR/J	MGP_AKRJ_G0021635	protein coding gene	Chr15:3375900-3431218 (+)
BALB/cJ	MGP_BALBcJ_G0021664	protein coding gene	Chr15:3284009-3337211 (+)
C3H/HeJ	MGP_C3HHeJ_G0021440	protein coding gene	Chr15:3403406-3459958 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022103	protein coding gene	Chr15:3570404-3626978 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019640	protein coding gene	Chr15:3029881-3080992 (+)
CAST/EiJ	MGP_CASTEiJ_G0020956	protein coding gene	Chr15:3383886-3441028 (+)
CBA/J	MGP_CBAJ_G0021409	protein coding gene	Chr15:3625339-3688095 (+)
DBA/2J	MGP_DBA2J_G0021533	protein coding gene	Chr15:3301499-3353858 (+)
FVB/NJ	MGP_FVBNJ_G0021511	protein coding gene	Chr15:3221508-3273288 (+)
LP/J	MGP_LPJ_G0021601	protein coding gene	Chr15:3346098-3401937 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021536	protein coding gene	Chr15:3835966-3895933 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022126	protein coding gene	Chr15:3397408-3452474 (+)
PWK/PhJ	MGP_PWKPhJ_G0020699	protein coding gene	Chr15:3297730-3353654 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020537	protein coding gene	Chr15:3319624-3377624 (+)
WSB/EiJ	MGP_WSBEiJ_G0021012	protein coding gene	Chr15:3314479-3369417 (+)

Human Ortholog

C9, complement C9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C9, complement C9
Synonyms

ARMD15, C9D
Links

HGNC:1358

NCBI Gene ID: 735

neXtProt AC: NX_P02748

UniProt: P02748
Chr Location

5p13.1; chr5:39284140-39371324 (-) GRCh38

MGI Vertebrate Homology

C9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: C9
Gene Tree

C9

Diseases

3 with human C9 associations

				Human Disease	Mouse Models
				age related macular degeneration 15 IDs age related macular degeneration 15 DOID:0110027 OMIM:615591
				complement component 9 deficiency IDs complement component 9 deficiency DOID:0060303 ICD10CM:D84.1 OMIM:613825 ORDO:169150
				opiate dependence IDs opiate dependence DOID:2559 ICD10CM:F11.2 ICD9CM_2006:304.0 ICD9CM:304.0 ICD9CM:304.00 MESH:D009293 UMLS_CUI:C0524662

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

7
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit impaired antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock.

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All GO Annotations

20
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

14
cDNA Data

24
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase c9

ZFIN c9

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All Sequences

41
RefSeq

6
UniProt

4
CCDS

CCDS27367.1

Ensembl

ENSMUSG00000022149 (Evidence)
NCBI Gene

12279

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022149	Ensembl Gene Model \| MGI Sequence Detail	53425	C57BL/6J	± kb
transcript	ENSMUST00000239466	Ensembl \| MGI Sequence Detail	1757	Not Applicable
polypeptide	ENSMUSP00000159308	Ensembl \| MGI Sequence Detail	561	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004911 complement component C9

(term hierarchy)
PDB

6CXO
InterPro Domains

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR036055 LDL receptor-like superfamily

IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site

IPR002172 Low-density lipoprotein (LDL) receptor class A repeat

IPR001862 Membrane attack complex component/perforin/complement C9

IPR020863 Membrane attack complex component/perforin domain, conserved site

IPR020864 Membrane attack complex component/perforin (MACPF) domain

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
GlyGen

P06683 3 sites, 2 N-linked glycans (2 sites)

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All nucleic 24

cDNA 24

Microarray probesets 3

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 14
Earliest

J:43388 Stanley KK, et al., Topological mapping of complement component C9 by recombinant DNA techniques suggests a novel mechanism for its insertion into target membranes. EMBO J. 1987 Jul;6(7):1951-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for C9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130493	Chr15:6474801-6474834 (+)	10 bp
Tssr130494	Chr15:6474844-6474857 (+)	43 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24