Per1 MGI Mouse Gene Detail - MGI:1098283 - period circadian clock 1

Symbol

Per1
Name

period circadian clock 1
Synonyms

Hftm, mPer1, m-rigui

Feature Type

protein coding gene
IDs

MGI:1098283
NCBI Gene: 18626
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr11:68986043-69000786 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.37 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

346 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098283	protein coding gene	Chr11:68985934-69000791 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018518	protein coding gene	Chr11:69500571-69515302 (+)
A/J	MGP_AJ_G0018487	protein coding gene	Chr11:66886706-66901442 (+)
AKR/J	MGP_AKRJ_G0018456	protein coding gene	Chr11:68890142-68904881 (+)
BALB/cJ	MGP_BALBcJ_G0018458	protein coding gene	Chr11:67208291-67222989 (+)
C3H/HeJ	MGP_C3HHeJ_G0018271	protein coding gene	Chr11:68906835-68921564 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018910	protein coding gene	Chr11:71611467-71627165 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016554	protein coding gene	Chr11:63826604-63841218 (+)
CAST/EiJ	MGP_CASTEiJ_G0017827	protein coding gene	Chr11:69144086-69158822 (+)
CBA/J	MGP_CBAJ_G0018245	protein coding gene	Chr11:74822298-74839849 (+)
DBA/2J	MGP_DBA2J_G0018354	protein coding gene	Chr11:66485530-66500177 (+)
FVB/NJ	MGP_FVBNJ_G0018344	protein coding gene	Chr11:66107037-66122224 (+)
LP/J	MGP_LPJ_G0018425	protein coding gene	Chr11:70087681-70102293 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018367	protein coding gene	Chr11:75449595-75464234 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018951	protein coding gene	Chr11:69135461-69150199 (+)
PWK/PhJ	MGP_PWKPhJ_G0017602	protein coding gene	Chr11:67122296-67137117 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017390	protein coding gene	Chr11:68968382-68983146 (+)
WSB/EiJ	MGP_WSBEiJ_G0017880	protein coding gene	Chr11:68775491-68790993 (+)

Human Ortholog

PER1, period circadian regulator 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PER1, period circadian regulator 1
Synonyms

hPER, PER, RIGUI
Links

HGNC:8845

NCBI Gene ID: 5187

neXtProt AC: NX_O15534

UniProt: O15534
Chr Location

17p13.1; chr17:8140472-8156506 (-) GRCh38

MGI Vertebrate Homology

Per1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PER1
Gene Tree

Per1

Diseases

1 with Per1 mouse models

Human Disease

Mouse Models

attention deficit hyperactivity disorder

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

27 phenotypes from 4 alleles in 8 genetic backgrounds
13 phenotypes from multigenic genotypes
132 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

9
Targeted

6
Transgenic

1
Genomic Mutations

1 involving Per1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

63 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display a persistent circadian rhythm, but they have a shorter period and their ability to maintain the precision and the stability of the period is impaired.

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All GO Annotations

65
GO References

38

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1088
Tissues

158
cDNA Data

64
Literature Summary

24

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase per1

ZFIN per1a, per1b

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All Sequences

66
RefSeq

14
UniProt

9
CCDS

CCDS24882.1

Ensembl

ENSMUSG00000020893 (Evidence)
NCBI Gene

18626

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020893	Ensembl Gene Model \| MGI Sequence Detail	14744	C57BL/6J	± kb
transcript	ENSMUST00000021271	Ensembl \| MGI Sequence Detail	4671	Not Applicable
polypeptide	ENSMUSP00000021271	Ensembl \| MGI Sequence Detail	1291	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000012547 period circadian protein homolog 1

(term hierarchy)
PDB

4DJ2
InterPro Domains

IPR000014 PAS domain

IPR035965 PAS domain superfamily

IPR013655 PAS fold-3

IPR022728 Period circadian-like, C-terminal

IPR048814 Period circadian protein homolog 1-3, PAS-A domain

IPR050760 Period circadian regulator
GlyGen

O35973 1 site, 1 O-linked glycan (1 site)

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All nucleic 78

Genomic 1

cDNA 67

Primer pair 8

Other 2

Microarray probesets 3

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MGI:3522286

Summaries

All 299

Developmental Gene Expression 24

Diseases 1

Gene Ontology 38

Phenotypes 132
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:358158 Sun J, et al., Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock. Cell Rep. 2024 Oct 22;43(10):114865

TSS for Per1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102402	Chr11:68986063-68986115 (+)	46 bp
Tssr102403	Chr11:68987396-68987400 (+)	1,355 bp
Tssr102404	Chr11:68988048-68988079 (+)	2,021 bp
Tssr102405	Chr11:68988557-68988570 (+)	2,521 bp
Tssr102406	Chr11:68988588-68988599 (+)	2,551 bp
Tssr102407	Chr11:68989549-68989554 (+)	3,509 bp
Tssr102408	Chr11:68989741-68989762 (+)	3,709 bp
Tssr102409	Chr11:68989763-68989811 (+)	3,744 bp
Tssr102410	Chr11:68989860-68989879 (+)	3,827 bp
Tssr102411	Chr11:68991846-68991853 (+)	5,807 bp
Tssr102412	Chr11:68994191-68994209 (+)	8,157 bp
Tssr102413	Chr11:68994473-68994517 (+)	8,452 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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