Astn1 MGI Mouse Gene Detail - MGI:1098567

Symbol

Astn1
Name

astrotactin 1
Synonyms

mKIAA0289

Feature Type

protein coding gene
IDs

MGI:1098567
NCBI Gene: 11899
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:158189843-158519351 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 68.35 cM, cytoband H1
Mapping Data

4 experiments

SNPs within 2kb

8640 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098567	protein coding gene	Chr1:158189647-158519351 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016635	protein coding gene	Chr1:163461895-163797516 (+)
A/J	MGP_AJ_G0016616	protein coding gene	Chr1:156829496-157158327 (+)
AKR/J	MGP_AKRJ_G0016582	protein coding gene	Chr1:161630472-161961407 (+)
BALB/cJ	MGP_BALBcJ_G0016577	protein coding gene	Chr1:157357784-157682270 (+)
C3H/HeJ	MGP_C3HHeJ_G0016401	protein coding gene	Chr1:161784973-162114701 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017038	protein coding gene	Chr1:169034267-169393183 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014747	protein coding gene	Chr1:149005206-149324296 (+)
CAST/EiJ	MGP_CASTEiJ_G0015981	protein coding gene	Chr1:161341686-161689947 (+)
CBA/J	MGP_CBAJ_G0016376	protein coding gene	Chr1:175027600-175369655 (+)
DBA/2J	MGP_DBA2J_G0016482	protein coding gene	Chr1:155784600-156110368 (+)
FVB/NJ	MGP_FVBNJ_G0016480	protein coding gene	Chr1:154232194-154557423 (+)
LP/J	MGP_LPJ_G0016553	protein coding gene	Chr1:164552077-164895420 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016505	protein coding gene	Chr1:182580971-182922303 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017074	protein coding gene	Chr1:161463563-161805522 (+)
PWK/PhJ	MGP_PWKPhJ_G0015767	protein coding gene	Chr1:154899919-155235294 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015554	protein coding gene	Chr1:160250057-160581468 (+)
WSB/EiJ	MGP_WSBEiJ_G0016043	protein coding gene	Chr1:161587178-161915657 (+)

Human Ortholog

ASTN1, astrotactin 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ASTN1, astrotactin 1
Synonyms

ASTN
Links

HGNC:773

NCBI Gene ID: 460

neXtProt AC: NX_O14525

UniProt: O14525
Chr Location

1q25.2; chr1:176857302-177164973 (-) GRCh38

MGI Vertebrate Homology

Astn1 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: ASTN1
Gene Tree

Astn1

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

4
Targeted

2
Genomic Mutations

2 involving Astn1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

85 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in reduced cerebellum size, abnormal Purkinje cell morphology, and reduced coordination performance on the Rotarod test.

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

773
Tissues

40
cDNA Data

97
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase astn1

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All Sequences

83
RefSeq

18
UniProt

8
CCDS

CCDS56648.1, CCDS78721.1

Ensembl

ENSMUSG00000026587 (Evidence)
NCBI Gene

11899

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026587	Ensembl Gene Model \| MGI Sequence Detail	329509	C57BL/6J	± kb
transcript	ENSMUST00000193042	Ensembl \| MGI Sequence Detail	7248	Not Applicable
polypeptide	ENSMUSP00000142322	Ensembl \| MGI Sequence Detail	1302	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000004389 astrotactin-1

(term hierarchy)
InterPro Domains

IPR040685 Annexin-like domain

IPR026995 Astrotactin

IPR045574 Astrotactin-1/2, Fn3 domain

IPR045575 Astrotactin-1/2, N-terminal

IPR000742 EGF-like domain

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR020864 Membrane attack complex component/perforin (MACPF) domain
GlyGen

Q61137 8 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 97

cDNA 97

Microarray probesets 3

Summaries

All 39

Developmental Gene Expression 8

Gene Ontology 6

Phenotypes 7
Earliest

J:192652 Fishell G, et al., Astrotactin provides a receptor system for CNS neuronal migration. Development. 1991 Nov;113(3):755-65
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Astn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9598	Chr1:158189659-158189672 (+)	-177 bp
Tssr9599	Chr1:158189750-158189762 (+)	-87 bp
Tssr9600	Chr1:158189831-158189866 (+)	6 bp
Tssr9601	Chr1:158189900-158189981 (+)	98 bp
Tssr9602	Chr1:158189988-158189998 (+)	150 bp
Tssr9603	Chr1:158190067-158190081 (+)	231 bp
Tssr9604	Chr1:158190091-158190155 (+)	280 bp
Tssr9605	Chr1:158379156-158379159 (+)	189,315 bp
Tssr9606	Chr1:158518874-158518885 (+)	329,037 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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