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Stag2 Gene Detail
Summary
  • Symbol
    Stag2
  • Name
    STAG2 cohesin complex component
  • Synonyms
    9230105L23Rik, B230112I07Rik, nuclear protein SA2, SA-2, SAP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098583
    NCBI Gene: 20843
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:41238194-41366062 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 23.19 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2195 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098583
 protein coding gene ChrX:41238172-41366063 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035675
 protein coding gene ChrX:37216897-37347720 (+)
A/J MGP_AJ_G0035658
 protein coding gene ChrX:37186948-37314973 (+)
AKR/J MGP_AKRJ_G0035578
 protein coding gene ChrX:38077280-38212771 (+)
BALB/cJ MGP_BALBcJ_G0035644
 protein coding gene ChrX:36862334-36990139 (+)
C3H/HeJ MGP_C3HHeJ_G0035348
 protein coding gene ChrX:37532616-37664991 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036173
 protein coding gene ChrX:38026096-38156626 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033025
 protein coding gene ChrX:35293830-35425628 (+)
CAST/EiJ MGP_CASTEiJ_G0034639
 protein coding gene ChrX:25368757-25501537 (+)
CBA/J MGP_CBAJ_G0035322
 protein coding gene ChrX:39038544-39176391 (+)
DBA/2J MGP_DBA2J_G0035476
 protein coding gene ChrX:36981969-37110350 (+)
FVB/NJ MGP_FVBNJ_G0035425
 protein coding gene ChrX:36716235-36850646 (+)
LP/J MGP_LPJ_G0035564
 protein coding gene ChrX:37530992-37661703 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035463
 protein coding gene ChrX:39782724-39927701 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036191
 protein coding gene ChrX:37169070-37299782 (+)
PWK/PhJ MGP_PWKPhJ_G0034338
 protein coding gene ChrX:24924658-25057971 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034183
 protein coding gene ChrX:25934281-26074351 (+)
WSB/EiJ MGP_WSBEiJ_G0034783
 protein coding gene ChrX:36818084-36950716 (+)



Homology
more
  • Human Ortholog
    STAG2, STAG2 cohesin complex component
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STAG2, STAG2 cohesin complex component
  • Synonyms
    bA517O1.1, HPE13, MKMS, NEDXCF, SA-2, SA2, SCC3B
  • Links
    NCBI Gene ID: 10735
    neXtProt AC: NX_Q8N3U4
    UniProt: Q8N3U4

  • Chr Location
    Xq25; chrX:123960212-124422664 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human STAG2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice hemizygous for a conditionally allele activated in embryos exhibit death at E10.5 with growth retardation and cardiac defects associated with reduced cell proliferation. Knockdown of expression of this gene results in lineage skewing of hematopoietic stem cells and myeloproliferative disorders in aged mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    856
  • Tissues
    106
  • cDNA Data
    129
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025862 Ensembl Gene Model | MGI Sequence Detail 127869 C57BL/6J ±  kb
    transcript ENSMUST00000115073 Ensembl | MGI Sequence Detail 6171 Not Applicable  
    polypeptide ENSMUSP00000110725 Ensembl | MGI Sequence Detail 1268 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      Genomic 2
      cDNA 130
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1925327, MGI:1925692
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 11
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:42879 Carramolino L, et al., SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs. Gene. 1997 Aug 22;195(2):151-9
    • Latest
      J:328115 Cheng N, et al., STAG2 promotes the myelination transcriptional program in oligodendrocytes. Elife. 2022 Aug 12;11:e77848
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory