Npy6r MGI Mouse Gene Detail - MGI:1098590 - neuropeptide Y receptor Y6

Symbol

Npy6r
Name

neuropeptide Y receptor Y6

Feature Type

protein coding gene
IDs

MGI:1098590
NCBI Gene: 18169
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr18:44403194-44410767 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 23.74 cM
Mapping Data

2 experiments

SNPs within 2kb

308 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098590	protein coding gene	Chr18:44403175-44410767 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024398	protein coding gene	Chr18:43008161-43015987 (+)
A/J	MGP_AJ_G0024365	protein coding gene	Chr18:41473897-41481462 (+)
AKR/J	MGP_AKRJ_G0024334	protein coding gene	Chr18:42640480-42648055 (+)
BALB/cJ	MGP_BALBcJ_G0024365	protein coding gene	Chr18:41568380-41575981 (+)
C3H/HeJ	MGP_C3HHeJ_G0024132	protein coding gene	Chr18:42668057-42675598 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024809	protein coding gene	Chr18:44505442-44513015 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022244	protein coding gene	Chr18:41267953-41275475 (+)
CAST/EiJ	MGP_CASTEiJ_G0023606	protein coding gene	Chr18:42659891-42667710 (+)
CBA/J	MGP_CBAJ_G0024101	protein coding gene	Chr18:45711118-45721946 (+)
DBA/2J	MGP_DBA2J_G0024231	protein coding gene	Chr18:41087232-41094767 (+)
FVB/NJ	MGP_FVBNJ_G0024197	protein coding gene	Chr18:40685245-40692830 (+)
LP/J	MGP_LPJ_G0024315	protein coding gene	Chr18:43031241-43038790 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024228	protein coding gene	Chr18:47086298-47095198 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024856	protein coding gene	Chr18:42509030-42516603 (+)
PWK/PhJ	MGP_PWKPhJ_G0023350	protein coding gene	Chr18:41282215-41289957 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023155	protein coding gene	Chr18:42740869-42754501 (+)
WSB/EiJ	MGP_WSBEiJ_G0023669	protein coding gene	Chr18:42433542-42442993 (+)

Human Ortholog

NPY6R, neuropeptide Y receptor Y6 (pseudogene)

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NPY6R, neuropeptide Y receptor Y6 (pseudogene)
Synonyms

NPY1RL, NPY6RP, PP2, Y2B
Links

HGNC:7959

NCBI Gene ID: 4888

UniProt: Q99463
Chr Location

5q31.2; chr5:137801193-137810755 (+) GRCh38

MGI Vertebrate Homology

Npy6r stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: NPY6R
Gene Tree

Npy6r

less

Phenotype Summary

41 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a reporter allele exhibit enhanced performance on the rotarod test.

less

All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

744
Tissues

25
cDNA Data

8
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS29227.1

Ensembl

ENSMUSG00000038071 (Evidence)
NCBI Gene

18169

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038071	Ensembl Gene Model \| MGI Sequence Detail	7574	C57BL/6J	± kb
transcript	ENSMUST00000042747	Ensembl \| MGI Sequence Detail	2567	Not Applicable
polypeptide	ENSMUSP00000040797	Ensembl \| MGI Sequence Detail	371	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000001624 neuropeptide Y receptor 6

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR000986 Neuropeptide Y6 receptor

IPR000611 Neuropeptide Y receptor family
GlyGen

Q61212 3 sites

less

All nucleic 17

Genomic 3

cDNA 8

Primer pair 1

Other 5

Microarray probesets 4

Summaries

All 32

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 6
Earliest

J:34096 Weinberg DH, et al., Cloning and expression of a novel neuropeptide Y receptor. J Biol Chem. 1996 Jul 12;271(28):16435-8
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Npy6r:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150906	Chr18:44403145-44403150 (+)	-46 bp
Tssr150907	Chr18:44403169-44403202 (+)	-8 bp
Tssr150908	Chr18:44403208-44403213 (+)	17 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24