Adam11 MGI Mouse Gene Detail - MGI:1098667 - a disintegrin and metallopeptidase domain 11

Symbol

Adam11
Name

a disintegrin and metallopeptidase domain 11
Synonyms

Mdc

Feature Type

protein coding gene
IDs

MGI:1098667
NCBI Gene: 11488
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:102652265-102671088 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 66.48 cM
Mapping Data

2 experiments

SNPs within 2kb

436 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098667	protein coding gene	Chr11:102652261-102671089 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019243	protein coding gene	Chr11:105779190-105802967 (+)
A/J	MGP_AJ_G0019211	protein coding gene	Chr11:101303600-101322397 (+)
AKR/J	MGP_AKRJ_G0019180	protein coding gene	Chr11:104436759-104455603 (+)
BALB/cJ	MGP_BALBcJ_G0019185	protein coding gene	Chr11:101781829-101800827 (+)
C3H/HeJ	MGP_C3HHeJ_G0018994	protein coding gene	Chr11:104650566-104670112 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019634	protein coding gene	Chr11:109066855-109085598 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017260	protein coding gene	Chr11:98730272-98749310 (+)
CAST/EiJ	MGP_CASTEiJ_G0018548	protein coding gene	Chr11:105655030-105673779 (+)
CBA/J	MGP_CBAJ_G0018963	protein coding gene	Chr11:113573744-113596070 (+)
DBA/2J	MGP_DBA2J_G0019075	protein coding gene	Chr11:100814240-100834268 (+)
FVB/NJ	MGP_FVBNJ_G0019065	protein coding gene	Chr11:100352086-100374151 (+)
LP/J	MGP_LPJ_G0019144	protein coding gene	Chr11:106297297-106318751 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019096	protein coding gene	Chr11:113037740-113056518 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019672	protein coding gene	Chr11:104811213-104830924 (+)
PWK/PhJ	MGP_PWKPhJ_G0018311	protein coding gene	Chr11:101889011-101912347 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018103	protein coding gene	Chr11:104565155-104585876 (+)
WSB/EiJ	MGP_WSBEiJ_G0018597	protein coding gene	Chr11:104804689-104825788 (+)

Human Ortholog

ADAM11, ADAM metallopeptidase domain 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADAM11, ADAM metallopeptidase domain 11
Synonyms

MDC
Links

HGNC:189

NCBI Gene ID: 4185

neXtProt AC: NX_O75078

UniProt: O75078
Chr Location

17q21.31; chr17:44758988-44781846 (+) GRCh38

MGI Vertebrate Homology

Adam11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADAM11
Gene Tree

Adam11

less

Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Gene trapped

1
Targeted

7
Genomic Mutations

1 involving Adam11
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available

Mice homozygous for a targeted disruption of this gene are viable and overtly normal but show impaired hippocampus-dependent spatial learning and cerebellum-dependent motor coordination when tested using water maze and rotating rod tasks.

less

All GO Annotations

17
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1071
Tissues

194
cDNA Data

34
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adam11

less

All Sequences

67
RefSeq

25
UniProt

3
CCDS

CCDS25503.1, CCDS48946.1

Ensembl

ENSMUSG00000020926 (Evidence)
NCBI Gene

11488

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020926	Ensembl Gene Model \| MGI Sequence Detail	18824	C57BL/6J	± kb
transcript	ENSMUST00000068150	Ensembl \| MGI Sequence Detail	5102	Not Applicable
polypeptide	ENSMUSP00000069466	Ensembl \| MGI Sequence Detail	778	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000003710 disintegrin and metalloproteinase domain-containing protein 11

(term hierarchy)
InterPro Domains

IPR006586 ADAM, cysteine-rich domain

IPR018358 Disintegrin, conserved site

IPR001762 Disintegrin domain

IPR036436 Disintegrin domain superfamily

IPR000742 EGF-like domain

IPR013111 EGF-like domain, extracellular

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR001590 Peptidase M12B, ADAM/reprolysin

IPR002870 Peptidase M12B, propeptide

IPR034027 Reprolysin domain, adamalysin-type
GlyGen

Q9R1V4 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

less

All nucleic 40

cDNA 34

Primer pair 1

Other 5

Microarray probesets 5

less

MGI:2144492

Summaries

All 48

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 16
Earliest

J:45793 Inoue D, et al., Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells. J Biol Chem. 1998 Feb 13;273(7):4180-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Adam11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105283	Chr11:102652228-102652274 (+)	-14 bp
Tssr105284	Chr11:102652389-102652446 (+)	153 bp
Tssr105285	Chr11:102664898-102664948 (+)	12,658 bp
Tssr105286	Chr11:102666048-102666053 (+)	13,786 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24