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Anapc4 Gene Detail
Summary
  • Symbol
    Anapc4
  • Name
    anaphase promoting complex subunit 4
  • Synonyms
    2610306D21Rik, APC4, D5Ertd249e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098673
    NCBI Gene: 52206
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:52991477-53024076 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 28.81 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    798 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098673
 protein coding gene Chr5:52991354-53025139 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029550
 protein coding gene Chr5:51835685-51873112 (+)
A/J MGP_AJ_G0029518
 protein coding gene Chr5:50028577-50062640 (+)
AKR/J MGP_AKRJ_G0029466
 protein coding gene Chr5:51719455-51757230 (+)
BALB/cJ MGP_BALBcJ_G0029527
 protein coding gene Chr5:50502930-50536605 (+)
C3H/HeJ MGP_C3HHeJ_G0029250
 protein coding gene Chr5:51880238-51916722 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029981
 protein coding gene Chr5:53989283-54023860 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027221
 protein coding gene Chr5:46787668-46822196 (+)
CAST/EiJ MGP_CASTEiJ_G0028658
 protein coding gene Chr5:50889809-50926102 (+)
CBA/J MGP_CBAJ_G0029219
 protein coding gene Chr5:55623700-55662884 (+)
DBA/2J MGP_DBA2J_G0029365
 protein coding gene Chr5:50078374-50113882 (+)
FVB/NJ MGP_FVBNJ_G0029325
 protein coding gene Chr5:49418742-49452293 (+)
LP/J MGP_LPJ_G0029450
 protein coding gene Chr5:52301557-52349668 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029353
 protein coding gene Chr5:56722087-56757652 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030014
 protein coding gene Chr5:51207504-51243010 (+)
PWK/PhJ MGP_PWKPhJ_G0028382
 protein coding gene Chr5:49146961-49181029 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028216
 protein coding gene Chr5:50652161-50687350 (+)
WSB/EiJ MGP_WSBEiJ_G0028739
 protein coding gene Chr5:51260347-51295103 (+)



Homology
more
  • Human Ortholog
    ANAPC4, anaphase promoting complex subunit 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANAPC4, anaphase promoting complex subunit 4
  • Synonyms
    APC4
  • Links
    NCBI Gene ID: 29945
    neXtProt AC: NX_Q9UJX5
    UniProt: Q9UJX5

  • Chr Location
    4p15.2; chr4:25377263-25418498 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic lethality. In culture, null cortical neurons display increased neurite formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    14
  • cDNA Data
    123
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 52206 NCBI Gene Model | MGI Sequence Detail 32600 C57BL/6J ±  kb
transcript NM_024213 RefSeq | MGI Sequence Detail 2668 ZRU/MplStud  
polypeptide Q91W96 UniProt | EBI | MGI Sequence Detail 807 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000004017 anaphase-promoting complex subunit 4
    (term hierarchy)
  • InterPro Domains
    IPR024789 Anaphase-promoting complex subunit 4
    IPR024977 Anaphase-promoting complex subunit 4-like, WD40 domain
    IPR024790 Anaphase-promoting complex subunit 4, long domain
    IPR017169 Anaphase-promoting complex subunit 4, metazoa
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Molecular
Reagents
less
  • All nucleic 124
    cDNA 123
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1915174
References
more
  • Summaries
    All 62
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 27
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:350417 Day JL, et al., Deletion of a core APC/C component reveals APC/C function in regulating neuronal USP1 levels and morphology. Front Mol Neurosci. 2024;17:1352782
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory