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Eif2a Gene Detail
Summary
  • Symbol
    Eif2a
  • Name
    eukaryotic translation initiation factor 2A
  • Synonyms
    D3Ertd194e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098684
    NCBI Gene: 229317
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:58433252-58464922 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 28.58 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    933 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098684
 protein coding gene Chr3:58433242-58464922 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027236
 protein coding gene Chr3:57366953-57401145 (+)
A/J MGP_AJ_G0027196
 protein coding gene Chr3:55583634-55615461 (+)
AKR/J MGP_AKRJ_G0027166
 protein coding gene Chr3:56724595-56756316 (+)
BALB/cJ MGP_BALBcJ_G0027209
 protein coding gene Chr3:55394231-55426533 (+)
C3H/HeJ MGP_C3HHeJ_G0026952
 protein coding gene Chr3:56945784-56979045 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027655
 protein coding gene Chr3:59476983-59511810 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025009
 protein coding gene Chr3:51925691-51961154 (+)
CAST/EiJ MGP_CASTEiJ_G0026404
 protein coding gene Chr3:57107835-57142797 (+)
CBA/J MGP_CBAJ_G0026928
 protein coding gene Chr3:61446030-61489213 (+)
DBA/2J MGP_DBA2J_G0027062
 protein coding gene Chr3:55078556-55110039 (+)
FVB/NJ MGP_FVBNJ_G0027030
 protein coding gene Chr3:54050314-54081949 (+)
LP/J MGP_LPJ_G0027174
 protein coding gene Chr3:58110521-58146569 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027048
 protein coding gene Chr3:65586577-65620783 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027713
 protein coding gene Chr3:56677781-56709767 (+)
PWK/PhJ MGP_PWKPhJ_G0026136
 protein coding gene Chr3:54724755-54761421 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025949
 protein coding gene Chr3:56351874-56383435 (+)
WSB/EiJ MGP_WSBEiJ_G0026478
 protein coding gene Chr3:56757329-56791309 (+)



Homology
more
  • Human Ortholog
    EIF2A, eukaryotic translation initiation factor 2A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF2A, eukaryotic translation initiation factor 2A
  • Synonyms
    CDA02, EIF-2A, MST089, MSTP004, MSTP089
  • Links
    NCBI Gene ID: 83939
    neXtProt AC: NX_Q9BY44
    UniProt: Q9BY44

  • Chr Location
    3q25.1; chr3:150546678-150586016 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable and fertile with no visible phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    20
  • cDNA Data
    9
  • Literature Summary
    47
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 229317 NCBI Gene Model | MGI Sequence Detail 31671 C57BL/6J ±  kb
    transcript NM_001005509 RefSeq | MGI Sequence Detail 2077 ZRU/MplStud  
    polypeptide Q8BJW6 UniProt | EBI | MGI Sequence Detail 581 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000006957 eukaryotic translation initiation factor 2A
      (term hierarchy)
    • InterPro Domains
      IPR011387 Translation initiation factor 2A
      IPR013979 Translation initiation factor, beta propellor-like domain
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q8BJW6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 47
      Diseases 1
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:19621 Ito T, et al., Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7455-9
    • Latest
      J:355649 Li Q, et al., Metabolic rewiring during bone development underlies tRNA m7G-associated primordial dwarfism. J Clin Invest. 2024 Sep 10;134(20)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory