Tmc6 MGI Mouse Gene Detail - MGI:1098686 - transmembrane channel-like gene family 6

Symbol

Tmc6
Name

transmembrane channel-like gene family 6
Synonyms

D11Ertd204e, EVER1

Feature Type

protein coding gene
IDs

MGI:1098686
NCBI Gene: 217353
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:117656811-117673019 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 82.96 cM
Mapping Data

2 experiments

SNPs within 2kb

448 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098686	protein coding gene	Chr11:117656811-117673024 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019449	protein coding gene	Chr11:122046791-122063141 (-)
A/J	MGP_AJ_G0019417	protein coding gene	Chr11:116635915-116652436 (-)
AKR/J	MGP_AKRJ_G0019387	protein coding gene	Chr11:120185267-120201565 (-)
BALB/cJ	MGP_BALBcJ_G0019392	protein coding gene	Chr11:117008400-117024584 (-)
C3H/HeJ	MGP_C3HHeJ_G0019198	protein coding gene	Chr11:120464381-120480678 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019841	protein coding gene	Chr11:125767010-125783915 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017466	protein coding gene	Chr11:113642429-113660702 (-)
CAST/EiJ	MGP_CASTEiJ_G0018752	protein coding gene	Chr11:121898817-121915036 (-)
CBA/J	MGP_CBAJ_G0019169	protein coding gene	Chr11:130725024-130742197 (-)
DBA/2J	MGP_DBA2J_G0019281	protein coding gene	Chr11:116036581-116052906 (-)
FVB/NJ	MGP_FVBNJ_G0019273	protein coding gene	Chr11:115656795-115673476 (-)
LP/J	MGP_LPJ_G0019351	protein coding gene	Chr11:122369678-122386031 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019306	protein coding gene	Chr11:129688853-129705029 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019880	protein coding gene	Chr11:120833033-120850131 (-)
PWK/PhJ	MGP_PWKPhJ_G0018518	protein coding gene	Chr11:117393703-117410119 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018310	protein coding gene	Chr11:120563026-120582093 (-)
WSB/EiJ	MGP_WSBEiJ_G0018804	protein coding gene	Chr11:120803672-120819942 (-)

Human Ortholog

TMC6, transmembrane channel like 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMC6, transmembrane channel like 6
Synonyms

EV1, EVER1, EVIN1, LAK-4P, lnc, TNRC6C-AS1
Links

HGNC:18021

NCBI Gene ID: 11322

neXtProt AC: NX_Q7Z403

UniProt: Q7Z403
Chr Location

17q25.3; chr17:78107397-78132427 (-) GRCh38

MGI Vertebrate Homology

Tmc6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMC6
Gene Tree

Tmc6

Diseases

1 with human TMC6 associations

				Human Disease	Mouse Models
				epidermodysplasia verruciformis IDs epidermodysplasia verruciformis DOID:13777 MESH:D004819 NCI:C126877 OMIM:PS226400 ORDO:302 UMLS_CUI:C0014522

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

8
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable, fertile and overtly normal with no major defects in T cell subset numbers or function.

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

82

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmc6

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All Sequences

111
RefSeq

32
UniProt

9
CCDS

CCDS25687.1, CCDS25688.1

Ensembl

ENSMUSG00000025572 (Evidence)
NCBI Gene

217353

			Length	Strain/Species	Flank
genomic	217353	NCBI Gene Model \| MGI Sequence Detail	16209	C57BL/6J	± kb
transcript	NM_145439	RefSeq \| MGI Sequence Detail	2945	ZRU/MplStud
polypeptide	Q7TN60	UniProt \| EBI \| MGI Sequence Detail	810	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000016397 transmembrane channel-like protein 6

(term hierarchy)
InterPro Domains

IPR012496 TMC domain

IPR038900 Transmembrane channel-like protein
GlyGen

Q7TN60 2 sites

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All nucleic 84

cDNA 83

Primer pair 1

Microarray probesets 2

Summaries

All 36

Gene Ontology 6

Phenotypes 11
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmc6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112039	Chr11:117673032-117673047 (-)	-21 bp
Tssr112038	Chr11:117673008-117673029 (-)	0 bp
Tssr112037	Chr11:117672981-117672993 (-)	32 bp
Tssr112036	Chr11:117671456-117671514 (-)	1,534 bp
Tssr112035	Chr11:117671439-117671455 (-)	1,572 bp
Tssr112034	Chr11:117671414-117671432 (-)	1,596 bp
Tssr112033	Chr11:117670431-117670457 (-)	2,575 bp
Tssr112032	Chr11:117669814-117669855 (-)	3,184 bp
Tssr112031	Chr11:117665864-117665875 (-)	7,149 bp
Tssr112030	Chr11:117665580-117665591 (-)	7,433 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24