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Sgta Gene Detail
Summary
  • Symbol
    Sgta
  • Name
    small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
  • Synonyms
    5330427H01Rik, D10Ertd190e, MGC:6336, Sgt
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098703
    NCBI Gene: 52551
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80879909-80896015 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    415 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098703
 protein coding gene Chr10:80879905-80896105 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017533
 protein coding gene Chr10:81720390-81736499 (-)
A/J MGP_AJ_G0017511
 protein coding gene Chr10:78838772-78854881 (-)
AKR/J MGP_AKRJ_G0017472
 protein coding gene Chr10:81001920-81018029 (-)
BALB/cJ MGP_BALBcJ_G0017473
 protein coding gene Chr10:79053760-79069869 (-)
C3H/HeJ MGP_C3HHeJ_G0017296
 protein coding gene Chr10:81084342-81100451 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017927
 protein coding gene Chr10:84531136-84547245 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015616
 protein coding gene Chr10:75048627-75061631 (-)
CAST/EiJ MGP_CASTEiJ_G0016863
 protein coding gene Chr10:81323933-81340234 (-)
CBA/J MGP_CBAJ_G0017268
 protein coding gene Chr10:87824647-87840724 (-)
DBA/2J MGP_DBA2J_G0017374
 protein coding gene Chr10:78033428-78049582 (-)
FVB/NJ MGP_FVBNJ_G0017368
 protein coding gene Chr10:77274049-77290126 (-)
LP/J MGP_LPJ_G0017445
 protein coding gene Chr10:82173116-82189290 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017394
 protein coding gene Chr10:89696229-89712338 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017968
 protein coding gene Chr10:80995509-81011618 (-)
PWK/PhJ MGP_PWKPhJ_G0016644
 protein coding gene Chr10:77932622-77949138 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016434
 protein coding gene Chr10:79944540-79960096 (-)
WSB/EiJ MGP_WSBEiJ_G0016923
 protein coding gene Chr10:81033000-81048977 (-)



Homology
more
  • Human Ortholog
    SGTA, small glutamine rich tetratricopeptide repeat co-chaperone alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SGTA, small glutamine rich tetratricopeptide repeat co-chaperone alpha
  • Synonyms
    alphaSGT, hSGT, SGT, SGT1, Vpu
  • Links
    NCBI Gene ID: 6449
    neXtProt AC: NX_O43765
    UniProt: O43765

  • Chr Location
    19p13.3; chr19:2754715-2783362 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased neonatal death, subfertility, decreased body size, increased brain, intestine and heart weight, decreased serum insulin-like growth factor I level, large penis, and increased testis descent.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    30
  • cDNA Data
    158
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004937 Ensembl Gene Model | MGI Sequence Detail 16107 C57BL/6J ±  kb
    transcript ENSMUST00000005067 Ensembl | MGI Sequence Detail 1969 Not Applicable  
    polypeptide ENSMUSP00000005067 Ensembl | MGI Sequence Detail 315 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000014807 small glutamine-rich tetratricopeptide repeat-containing protein alpha
      (term hierarchy)
    • InterPro Domains
      IPR047150 SGT
      IPR032374 SGTA, homodimerisation domain
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
    • GlyGen
      Q8BJU0 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 160
      cDNA 159
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1915341, MGI:2143532
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory