Psmc3 MGI Mouse Gene Detail - MGI:1098754 - proteasome (prosome, macropain) 26S subunit, ATPase 3

Symbol

Psmc3
Name

proteasome (prosome, macropain) 26S subunit, ATPase 3
Synonyms

Tat binding protein 1, TBP-1

Feature Type

protein coding gene
IDs

MGI:1098754
NCBI Gene: 19182
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr2:90884361-90889783 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 50.44 cM
Mapping Data

2 experiments

SNPs within 2kb

157 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098754	protein coding gene	Chr2:90884354-90896714 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026139	protein coding gene	Chr2:92354752-92367105 (+)
A/J	MGP_AJ_G0026100	protein coding gene	Chr2:88661309-88673665 (+)
AKR/J	MGP_AKRJ_G0026081	protein coding gene	Chr2:91114854-91127208 (+)
BALB/cJ	MGP_BALBcJ_G0026109	protein coding gene	Chr2:88826396-88838756 (+)
C3H/HeJ	MGP_C3HHeJ_G0025860	protein coding gene	Chr2:91389999-91403423 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026560	protein coding gene	Chr2:95612224-95624582 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023951	protein coding gene	Chr2:85179029-85191466 (+)
CAST/EiJ	MGP_CASTEiJ_G0025325	protein coding gene	Chr2:91912990-91927174 (+)
CBA/J	MGP_CBAJ_G0025838	protein coding gene	Chr2:98856148-98873144 (+)
DBA/2J	MGP_DBA2J_G0025974	protein coding gene	Chr2:88259985-88272345 (+)
FVB/NJ	MGP_FVBNJ_G0025937	protein coding gene	Chr2:87366479-87378835 (+)
LP/J	MGP_LPJ_G0026078	protein coding gene	Chr2:92561842-92574202 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025963	protein coding gene	Chr2:101902407-101914767 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026614	protein coding gene	Chr2:91172996-91185356 (+)
PWK/PhJ	MGP_PWKPhJ_G0025060	protein coding gene	Chr2:87988609-88001051 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024861	protein coding gene	Chr2:90755189-90767739 (+)
WSB/EiJ	MGP_WSBEiJ_G0025392	protein coding gene	Chr2:91765154-91777511 (+)

Human Ortholog

PSMC3, proteasome 26S subunit, ATPase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PSMC3, proteasome 26S subunit, ATPase 3
Synonyms

DCIDP, RPT5, TBP1
Links

HGNC:9549

NCBI Gene ID: 5702

neXtProt AC: NX_P17980

UniProt: P17980
Chr Location

11p11.2; chr11:47418769-47426473 (-) GRCh38

MGI Vertebrate Homology

Psmc3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PSMC3
Gene Tree

Psmc3

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

4
Radiation induced

1
Targeted

6
Genomic Mutations

4 involving Psmc3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available

Mice homozygous for disruptions in this gene die as embryos.

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All GO Annotations

12
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

817
Tissues

111
cDNA Data

314
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PSMC3

Xenbase psmc3

ZFIN psmc3

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All Sequences

68
RefSeq

2
UniProt

11
CCDS

CCDS16423.1

Ensembl

ENSMUSG00000002102 (Evidence)
NCBI Gene

19182

			Length	Strain/Species	Flank
genomic	19182	NCBI Gene Model \| MGI Sequence Detail	5423	C57BL/6J	± kb
transcript	NM_008948	RefSeq \| MGI Sequence Detail	1651	ZRU/MplStud
polypeptide	O88685	UniProt \| EBI \| MGI Sequence Detail	442	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000013380 26S proteasome regulatory subunit 6A

(term hierarchy)
InterPro Domains

IPR050221 26S Proteasome Regulatory ATPase

IPR041569 AAA ATPase, AAA+ lid domain

IPR003593 AAA+ ATPase domain

IPR003960 ATPase, AAA-type, conserved site

IPR003959 ATPase, AAA-type, core

IPR012340 Nucleic acid-binding, OB-fold

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR032501 Proteasomal ATPase, second OB domain
GlyGen

O88685 1 site, 1 N-linked glycan (1 site)

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All nucleic 315

cDNA 314

Primer pair 1

Microarray probesets 6

Summaries

All 45

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Psmc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18821	Chr2:90884370-90884383 (+)	16 bp
Tssr18822	Chr2:90884399-90884459 (+)	68 bp
Tssr18823	Chr2:90884464-90884477 (+)	110 bp
Tssr18824	Chr2:90884481-90884486 (+)	123 bp
Tssr18825	Chr2:90884489-90884520 (+)	144 bp
Tssr18826	Chr2:90884524-90884543 (+)	173 bp
Tssr18827	Chr2:90884552-90884584 (+)	207 bp
Tssr18828	Chr2:90884608-90884648 (+)	267 bp
Tssr18829	Chr2:90884929-90884949 (+)	578 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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