Cdk2ap2 MGI Mouse Gene Detail - MGI:1098779 - cyclin dependent kinase 2 associated protein 2

Symbol

Cdk2ap2
Name

cyclin dependent kinase 2 associated protein 2
Synonyms

5830466O21Rik

Feature Type

protein coding gene
IDs

MGI:1098779
NCBI Gene: 52004
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr19:4147182-4149019 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 3.80 cM
Mapping Data

3 experiments

SNPs within 2kb

17 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098779	protein coding gene	Chr19:4146204-4149019 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024645	protein coding gene	Chr19:930305-931923 (+)
A/J	MGP_AJ_G0024611	protein coding gene	Chr19:899397-901015 (+)
AKR/J	MGP_AKRJ_G0024584	protein coding gene	Chr19:923577-925195 (+)
BALB/cJ	MGP_BALBcJ_G0024611	protein coding gene	Chr19:887531-889149 (+)
C3H/HeJ	MGP_C3HHeJ_G0024379	protein coding gene	Chr19:917767-919385 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025059	protein coding gene	Chr19:965198-966816 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022488	protein coding gene	Chr19:840646-842263 (+)
CAST/EiJ	MGP_CASTEiJ_G0023851	protein coding gene	Chr19:925535-927153 (+)
CBA/J	MGP_CBAJ_G0024350	protein coding gene	Chr19:1026400-1028018 (+)
DBA/2J	MGP_DBA2J_G0024478	protein coding gene	Chr19:858380-859998 (+)
FVB/NJ	MGP_FVBNJ_G0024445	protein coding gene	Chr19:866659-868277 (+)
LP/J	MGP_LPJ_G0024564	protein coding gene	Chr19:925558-927176 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024475	protein coding gene	Chr19:975442-977060 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025106	protein coding gene	Chr19:918357-919975 (+)
PWK/PhJ	MGP_PWKPhJ_G0023597	protein coding gene	Chr19:909246-910864 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023402	protein coding gene	Chr19:901488-903098 (+)
WSB/EiJ	MGP_WSBEiJ_G0023913	protein coding gene	Chr19:905282-906900 (+)

Human Ortholog

CDK2AP2, cyclin dependent kinase 2 associated protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDK2AP2, cyclin dependent kinase 2 associated protein 2
Synonyms

DOC-1R, DOC1R, p14
Links

HGNC:30833

NCBI Gene ID: 10263

neXtProt AC: NX_O75956

UniProt: O75956
Chr Location

11q13.2; chr11:67506497-67508649 (-) GRCh38

MGI Vertebrate Homology

Cdk2ap2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDK2AP2
Protein SuperFamily

CDK2-associated_p2
Gene Tree

Cdk2ap2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

1
Gene trapped

6
Targeted

2
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

76

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cdk2ap2

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All Sequences

46
RefSeq

4
UniProt

3
CCDS

CCDS29414.1

Ensembl

ENSMUSG00000024856 (Evidence)
NCBI Gene

52004

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024856	Ensembl Gene Model \| MGI Sequence Detail	1838	C57BL/6J	± kb
transcript	ENSMUST00000025779	Ensembl \| MGI Sequence Detail	1080	Not Applicable
polypeptide	ENSMUSP00000025779	Ensembl \| MGI Sequence Detail	127	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005255 cyclin-dependent kinase 2-associated protein 2

(term hierarchy)
InterPro Domains

IPR017266 Cyclin-dependent kinase 2-associated protein 1/2

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All nucleic 77

cDNA 76

Primer pair 1

Microarray probesets 3

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MGI:1915027

Summaries

All 31

Gene Ontology 5

Phenotypes 7
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cdk2ap2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154261	Chr19:4146880-4146945 (+)	-269 bp
Tssr154262	Chr19:4147337-4147356 (+)	165 bp
Tssr154263	Chr19:4147369-4147386 (+)	196 bp
Tssr154264	Chr19:4147392-4147415 (+)	222 bp
Tssr154265	Chr19:4147422-4147432 (+)	245 bp
Tssr154266	Chr19:4147445-4147451 (+)	266 bp
Tssr154267	Chr19:4147678-4147713 (+)	514 bp
Tssr154268	Chr19:4147800-4147809 (+)	623 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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