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Ccl25 Gene Detail
Summary
  • Symbol
    Ccl25
  • Name
    C-C motif chemokine ligand 25
  • Synonyms
    CKb15, Scya25, TECK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099448
    NCBI Gene: 20300
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:4375210-4410020 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 2.01 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    928 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099448
 protein coding gene Chr8:4375207-4410020 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033334
 protein coding gene Chr8:1311773-1349724 (+)
A/J MGP_AJ_G0033315
 protein coding gene Chr8:1259832-1297482 (+)
AKR/J MGP_AKRJ_G0033246
 protein coding gene Chr8:1298242-1338546 (+)
BALB/cJ MGP_BALBcJ_G0033315
 protein coding gene Chr8:1314466-1349454 (+)
C3H/HeJ MGP_C3HHeJ_G0033029
 protein coding gene Chr8:1308020-1343956 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033827
 protein coding gene Chr8:1352663-1394134 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030799
 protein coding gene Chr8:1140358-1175327 (+)
CAST/EiJ MGP_CASTEiJ_G0032352
 protein coding gene Chr8:1189861-1226991 (+)
CBA/J MGP_CBAJ_G0033002
 protein coding gene Chr8:1390478-1434674 (+)
DBA/2J MGP_DBA2J_G0033156
 protein coding gene Chr8:1220160-1254934 (+)
FVB/NJ MGP_FVBNJ_G0033103
 protein coding gene Chr8:1260620-1303017 (+)
LP/J MGP_LPJ_G0033250
 protein coding gene Chr8:1235345-1280998 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033138
 protein coding gene Chr8:1370214-1408683 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033844
 protein coding gene Chr8:1279899-1318902 (+)
PWK/PhJ MGP_PWKPhJ_G0032064
 protein coding gene Chr8:1185668-1221095 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031907
 protein coding gene Chr8:1211560-1244365 (+)
WSB/EiJ MGP_WSBEiJ_G0032467
 protein coding gene Chr8:1260392-1296171 (+)



Homology
more
  • Human Ortholog
    CCL25, C-C motif chemokine ligand 25
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCL25, C-C motif chemokine ligand 25
  • Synonyms
    Ckb15, Ck beta-15, SCYA25, TECK, TECKvar
  • Links
    NCBI Gene ID: 6370
    neXtProt AC: NX_O15444
    UniProt: O15444

  • Chr Location
    19p13.2; chr19:8052318-8062660 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired accumulation of antigen-specific CD8+ T lymphocytes within both lamina propria and epithelium of the small intestine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    36
  • cDNA Data
    26
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023235 Ensembl Gene Model | MGI Sequence Detail 34811 C57BL/6J ±  kb
    transcript ENSMUST00000127460 Ensembl | MGI Sequence Detail 867 Not Applicable  
    polypeptide ENSMUSP00000120719 Ensembl | MGI Sequence Detail 228 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 26
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142637
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 16
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:42501 Vicari AP, et al., TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity. 1997 Aug;7(2):291-301
    • Latest
      J:352089 Grammer C, et al., Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development. iScience. 2024 Jul 19;27(7):110258
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory