Plk2 MGI Mouse Gene Detail - MGI:1099790

Symbol

Plk2
Name

polo like kinase 2
Synonyms

Snk

Feature Type

protein coding gene
IDs

MGI:1099790
NCBI Gene: 20620
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr13:110531580-110537378 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 61.97 cM, cytoband D2.1
Mapping Data

1 experiment

SNPs within 2kb

250 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1099790	protein coding gene	Chr13:110531578-110537378 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020930	protein coding gene	Chr13:112803198-112810378 (+)
A/J	MGP_AJ_G0020880	protein coding gene	Chr13:108350517-108356404 (+)
AKR/J	MGP_AKRJ_G0020855	protein coding gene	Chr13:111615580-111621354 (+)
BALB/cJ	MGP_BALBcJ_G0020880	protein coding gene	Chr13:109045775-109051680 (+)
C3H/HeJ	MGP_C3HHeJ_G0020669	protein coding gene	Chr13:111387059-111393811 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021315	protein coding gene	Chr13:116186460-116193378 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018884	protein coding gene	Chr13:103726409-103732153 (+)
CAST/EiJ	MGP_CASTEiJ_G0020188	protein coding gene	Chr13:110985485-110993549 (+)
CBA/J	MGP_CBAJ_G0020631	protein coding gene	Chr13:120647990-120655686 (+)
DBA/2J	MGP_DBA2J_G0020754	protein coding gene	Chr13:108067384-108073594 (+)
FVB/NJ	MGP_FVBNJ_G0020737	protein coding gene	Chr13:106750762-106756543 (+)
LP/J	MGP_LPJ_G0020829	protein coding gene	Chr13:112876868-112884435 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020765	protein coding gene	Chr13:121034440-121041288 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021353	protein coding gene	Chr13:111057414-111064484 (+)
PWK/PhJ	MGP_PWKPhJ_G0019941	protein coding gene	Chr13:106775551-106803798 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019763	protein coding gene	Chr13:107336360-107342857 (+)
WSB/EiJ	MGP_WSBEiJ_G0020246	protein coding gene	Chr13:111636023-111642933 (+)

Human Ortholog

PLK2, polo like kinase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLK2, polo like kinase 2
Synonyms

hPlk2, hSNK, SNK
Links

HGNC:19699

NCBI Gene ID: 10769

neXtProt AC: NX_Q9NYY3

UniProt: Q9NYY3
Chr Location

5q11.2; chr5:58453982-58460139 (-) GRCh38

MGI Vertebrate Homology

Plk2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PLK2
Gene Tree

Plk2

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Inactivation of this gene results in impaired embryonic growth and placental defects due to increased cell proliferation.

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All GO Annotations

67
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

972
Tissues

120
cDNA Data

117
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plk2

ZFIN plk2a, plk2b

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All Sequences

44
RefSeq

2
UniProt

4
CCDS

CCDS26767.1

Ensembl

ENSMUSG00000021701 (Evidence)
NCBI Gene

20620

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021701	Ensembl Gene Model \| MGI Sequence Detail	5799	C57BL/6J	± kb
transcript	ENSMUST00000022212	Ensembl \| MGI Sequence Detail	2800	Not Applicable
polypeptide	ENSMUSP00000022212	Ensembl \| MGI Sequence Detail	682	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012871 serine/threonine-protein kinase PLK2

(term hierarchy)
EC

2.7.11.21
InterPro Domains

IPR033701 First polo-box domain

IPR042825 PLK2, catalytic domain

IPR000959 POLO box domain

IPR036947 POLO box domain superfamily

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR033695 Second polo-box domain

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 118

cDNA 117

Primer pair 1

Microarray probesets 3

Summaries

All 57

Developmental Gene Expression 7

Gene Ontology 13

Phenotypes 13
Earliest

J:43404 Simmons DL, et al., Identification of an early-growth-response gene encoding a novel putative protein kinase. Mol Cell Biol. 1992 Sep;12(9):4164-9
Latest

J:328712 Du H, et al., Transcription factors Bcl11a and Bcl11b are required for the production and differentiation of cortical projection neurons. Cereb Cortex. 2022 Aug 22;32(17):3611-3632

TSS for Plk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121036	Chr13:110531014-110531032 (+)	-557 bp
Tssr121037	Chr13:110531132-110531167 (+)	-430 bp
Tssr121038	Chr13:110531575-110531591 (+)	3 bp
Tssr121039	Chr13:110532506-110532513 (+)	930 bp
Tssr121040	Chr13:110532614-110532634 (+)	1,044 bp
Tssr121041	Chr13:110533146-110533181 (+)	1,584 bp
Tssr121042	Chr13:110533305-110533318 (+)	1,732 bp
Tssr121043	Chr13:110533364-110533375 (+)	1,790 bp
Tssr121044	Chr13:110533467-110533493 (+)	1,900 bp
Tssr121045	Chr13:110533525-110533536 (+)	1,951 bp
Tssr121046	Chr13:110533657-110533675 (+)	2,086 bp
Tssr121047	Chr13:110534012-110534043 (+)	2,448 bp
Tssr121048	Chr13:110534503-110534526 (+)	2,935 bp
Tssr121049	Chr13:110536327-110536347 (+)	4,757 bp
Tssr121050	Chr13:110536351-110536367 (+)	4,779 bp
Tssr121051	Chr13:110536501-110536505 (+)	4,923 bp
Tssr121052	Chr13:110537119-110537139 (+)	5,549 bp
Tssr121053	Chr13:110537147-110537172 (+)	5,580 bp
Tssr121054	Chr13:110537220-110537224 (+)	5,642 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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