Ptpn4 MGI Mouse Gene Detail - MGI:1099792 - protein tyrosine phosphatase, non-receptor type 4

Symbol

Ptpn4
Name

protein tyrosine phosphatase, non-receptor type 4
Synonyms

hPTP-MEG, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), PTPMEG, TEP, TEP/mPTPMEG, testis-enriched phosphatase

Feature Type

protein coding gene
IDs

MGI:1099792
NCBI Gene: 19258
Alliance

gene page
Transcription Start Sites

8 TSS
Candidate for QTL

1 QTL

Sequence Map

Chr1:119580197-119765281 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 52.39 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

2939 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1099792	protein coding gene	Chr1:119580197-119765343 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016398	protein coding gene	Chr1:122410595-122611769 (-)
A/J	MGP_AJ_G0016381	protein coding gene	Chr1:118024165-118211088 (-)
AKR/J	MGP_AKRJ_G0016346	protein coding gene	Chr1:121511463-121691758 (-)
BALB/cJ	MGP_BALBcJ_G0016341	protein coding gene	Chr1:118288558-118470943 (-)
C3H/HeJ	MGP_C3HHeJ_G0016167	protein coding gene	Chr1:121677395-121857124 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016802	protein coding gene	Chr1:127094817-127282003 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014515	protein coding gene	Chr1:111685951-111865164 (-)
CAST/EiJ	MGP_CASTEiJ_G0015748	protein coding gene	Chr1:120448470-120644705 (-)
CBA/J	MGP_CBAJ_G0016140	protein coding gene	Chr1:131471207-131667411 (-)
DBA/2J	MGP_DBA2J_G0016246	protein coding gene	Chr1:117044746-117237145 (-)
FVB/NJ	MGP_FVBNJ_G0016245	protein coding gene	Chr1:115792992-115983751 (-)
LP/J	MGP_LPJ_G0016317	protein coding gene	Chr1:123747946-123945413 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016270	protein coding gene	Chr1:137189573-137424716 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016838	protein coding gene	Chr1:121213872-121402897 (-)
PWK/PhJ	MGP_PWKPhJ_G0015534	protein coding gene	Chr1:116032966-116211388 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015322	protein coding gene	Chr1:120118193-120303620 (-)
WSB/EiJ	MGP_WSBEiJ_G0015810	protein coding gene	Chr1:121096385-121288889 (-)

Human Ortholog

PTPN4, protein tyrosine phosphatase non-receptor type 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPN4, protein tyrosine phosphatase non-receptor type 4
Synonyms

MEG, PTPMEG, PTPMEG1
Links

HGNC:9656

NCBI Gene ID: 5775

neXtProt AC: NX_P29074

UniProt: P29074
Chr Location

2q14.2; chr2:119759922-119984899 (+) GRCh38

MGI Vertebrate Homology

Ptpn4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PTPN4
Protein SuperFamily

Tyr-Ptase_nr3
Gene Tree

Ptpn4

less

Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

2
Gene trapped

14
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving Ptpn4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

50 strains or lines available

Mice homozygous for a null allele exhibit impaired coordination, abnormal eye blink conditioning behavior, and reduced long term depression.

less

All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

40
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptpn4

less

All Sequences

80
RefSeq

20
UniProt

12
CCDS

CCDS15227.1

Ensembl

ENSMUSG00000026384 (Evidence)
NCBI Gene

19258

			Length	Strain/Species	Flank
genomic	19258	NCBI Gene Model \| MGI Sequence Detail	185085	C57BL/6J	± kb
transcript	NM_019933	RefSeq \| MGI Sequence Detail	4707	ZRU/MplStud
polypeptide	Q9WU22	UniProt \| EBI \| MGI Sequence Detail	926	Not Applicable

less

UniProt

12 Sequences
Protein Ontology

PR:000013459 tyrosine-protein phosphatase non-receptor type 4

(term hierarchy)
EC

3.1.3.48
InterPro Domains

IPR019749 Band 4.1 domain

IPR000798 Ezrin/radixin/moesin-like

IPR014352 FERM/acyl-CoA-binding protein superfamily

IPR014847 FERM adjacent

IPR019748 FERM central domain

IPR019747 FERM conserved site

IPR018980 FERM, C-terminal PH-like domain

IPR000299 FERM domain

IPR018979 FERM, N-terminal

IPR035963 FERM superfamily, second domain

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR011993 PH-like domain superfamily

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR012151 Protein-tyrosine phosphatase, non-receptor type-3, -4

IPR041783 PTPN3/4, FERM domain C-lobe

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain

IPR029071 Ubiquitin-like domain superfamily

less

All nucleic 17

cDNA 14

Primer pair 3

Microarray probesets 3

Summaries

All 50

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 15
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:350469 Alderman PJ, et al., Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala. Neuron. 2024 Feb 21;112(4):574-592.e10

TSS for Ptpn4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13225	Chr1:119765397-119765403 (-)	-119 bp
Tssr13224	Chr1:119765196-119765285 (-)	40 bp
Tssr13223	Chr1:119765068-119765116 (-)	189 bp
Tssr13222	Chr1:119765049-119765058 (-)	227 bp
Tssr13221	Chr1:119765018-119765029 (-)	257 bp
Tssr13220	Chr1:119764818-119764869 (-)	437 bp
Tssr13219	Chr1:119755817-119755822 (-)	9,461 bp
Tssr13218	Chr1:119749042-119749046 (-)	16,237 bp

Ptpn4 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Lore1	Chr1, 44.69 cM	Chr1:75549191-92941077	J:93175	Potential candidate genes mapping near Lore1 on mouse Chromosome 1 are Pthr2, Ptpn4, Zfp142 (41.5 cM), and Htr5b (63 cM). Pthr2, Ptpn4, and Zfp142 have been sequenced and are polymorphic between inbred strains LS and IS.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24