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Tln1 Gene Detail
Summary
  • Symbol
    Tln1
  • Name
    talin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099832
    NCBI Gene: 21894
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43531513-43562583 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    608 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099832
 protein coding gene Chr4:43531513-43562691 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028212
 protein coding gene Chr4:41652062-41684410 (-)
A/J MGP_AJ_G0028168
 protein coding gene Chr4:40173304-40204388 (-)
AKR/J MGP_AKRJ_G0028120
 protein coding gene Chr4:41085665-41116602 (-)
BALB/cJ MGP_BALBcJ_G0028188
 protein coding gene Chr4:40262595-40294470 (-)
C3H/HeJ MGP_C3HHeJ_G0027910
 protein coding gene Chr4:41714206-41746228 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028629
 protein coding gene Chr4:43214008-43246664 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025941
 protein coding gene Chr4:37620714-37652698 (-)
CAST/EiJ MGP_CASTEiJ_G0027350
 protein coding gene Chr4:41219447-41251843 (-)
CBA/J MGP_CBAJ_G0027876
 protein coding gene Chr4:44523549-44565521 (-)
DBA/2J MGP_DBA2J_G0028025
 protein coding gene Chr4:40082004-40114171 (-)
FVB/NJ MGP_FVBNJ_G0027992
 protein coding gene Chr4:39304474-39336949 (-)
LP/J MGP_LPJ_G0028124
 protein coding gene Chr4:41704860-41741205 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028016
 protein coding gene Chr4:47787617-47820281 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028665
 protein coding gene Chr4:41284967-41318588 (-)
PWK/PhJ MGP_PWKPhJ_G0027076
 protein coding gene Chr4:40124725-40156782 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026902
 protein coding gene Chr4:40849829-40880784 (-)
WSB/EiJ MGP_WSBEiJ_G0027430
 protein coding gene Chr4:41186859-41219103 (-)



Homology
more
  • Human Ortholog
    TLN1, talin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLN1, talin 1
  • Synonyms
    ILWEQ, talin-1, TLN
  • Links
    NCBI Gene ID: 7094
    neXtProt AC: NX_Q9Y490
    UniProt: Q9Y490

  • Chr Location
    9p13.3; chr9:35696948-35732195 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 5 alleles in 6 genetic backgrounds
    9 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for either one of two knock-out alleles display early developmental anomalies, reduced embryo size, and embryonic lethality due to impaired cell migration at the gastrulation stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    929
  • Tissues
    23
  • cDNA Data
    14
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21894 NCBI Gene Model | MGI Sequence Detail 31071 C57BL/6J ±  kb
    transcript NM_011602 RefSeq | MGI Sequence Detail 8560 C57BL/6  
    polypeptide P26039 UniProt | EBI | MGI Sequence Detail 2541 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 6
    References
    more
    • Summaries
      All 154
      Developmental Gene Expression 21
      Gene Ontology 23
      Phenotypes 64
    • Earliest
      J:43417 Rees DJ, et al., Sequence and domain structure of talin. Nature. 1990 Oct 18;347(6294):685-9
    • Latest
      J:347281 Horitani S, et al., The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for pulmonary transit and egress from the lymph nodes. Front Immunol. 2023;14:1234747
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory