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Myt1l Gene Detail
Summary
  • Symbol
    Myt1l
  • Name
    myelin transcription factor 1-like
  • Synonyms
    2900046C06Rik, 2900093J19Rik, C630034G21Rik, mKIAA1106, Nztf1, Pmng1, Png-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100511
    NCBI Gene: 17933
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:29578383-29973212 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 11.86 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10775 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100511
 protein coding gene Chr12:29578375-29973215 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019648
 protein coding gene Chr12:27397749-27811854 (+)
A/J MGP_AJ_G0019615
 protein coding gene Chr12:26636534-27043741 (+)
AKR/J MGP_AKRJ_G0019586
 protein coding gene Chr12:27531567-27935725 (+)
BALB/cJ MGP_BALBcJ_G0019592
 protein coding gene Chr12:26892383-27296587 (+)
C3H/HeJ MGP_C3HHeJ_G0019396
 protein coding gene Chr12:27378602-27783897 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020039
 protein coding gene Chr12:28281269-28689784 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017664
 protein coding gene Chr12:25991288-26384321 (+)
CAST/EiJ MGP_CASTEiJ_G0018951
 protein coding gene Chr12:22361090-22776238 (+)
CBA/J MGP_CBAJ_G0019367
 protein coding gene Chr12:29252480-29659433 (+)
DBA/2J MGP_DBA2J_G0019481
 protein coding gene Chr12:26488324-26887674 (+)
FVB/NJ MGP_FVBNJ_G0019472
 protein coding gene Chr12:26299752-26701784 (+)
LP/J MGP_LPJ_G0019551
 protein coding gene Chr12:27486488-27902250 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019507
 protein coding gene Chr12:28846218-29257042 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020079
 protein coding gene Chr12:27051360-27459566 (+)
PWK/PhJ MGP_PWKPhJ_G0018718
 protein coding gene Chr12:21210270-21611269 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018506
 protein coding gene Chr12:21645739-22048278 (+)
WSB/EiJ MGP_WSBEiJ_G0019002
 protein coding gene Chr12:27264942-27670380 (+)



Homology
more
  • Human Ortholog
    MYT1L, myelin transcription factor 1 like
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYT1L, myelin transcription factor 1 like
  • Synonyms
    MRD39, myT1-L, NZF1, ZC2H2C2, ZC2HC4B
  • Links
    NCBI Gene ID: 23040
    neXtProt AC: NX_Q9UL68
    UniProt: Q9UL68

  • Chr Location
    2p25.3; chr2:1789113-2331664 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Myt1l mouse models; 1 with human MYT1L associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show neonatal lethality. Heterozygous pups show altered communication while adults become overweight, show hyperactivity due to impaired habituation, reduced motor performance and anxiety, enhanced startle reflex and nest building, and impaired contextual conditioning behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1069
  • Tissues
    294
  • cDNA Data
    29
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061911 Ensembl Gene Model | MGI Sequence Detail 394830 C57BL/6J ±  kb
    transcript ENSMUST00000049784 Ensembl | MGI Sequence Detail 7202 Not Applicable  
    polypeptide ENSMUSP00000058264 Ensembl | MGI Sequence Detail 1187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010893 myelin transcription factor 1-like protein
      (term hierarchy)
    • InterPro Domains
      IPR013681 Myelin transcription factor 1
      IPR002515 Zinc finger, C2H2C-type
      IPR036060 Zinc finger, C2H2C-type superfamily
    • GlyGen
      P97500 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 32
      Primer pair 5

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-36441, MGI:107864, MGI:1920146, MGI:1920316, MGI:2443117, MGI:891972
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 28
      Diseases 2
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:39021 Jiang Y, et al., A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland. J Biol Chem. 1996 May 3;271(18):10723-30
    • Latest
      J:359190 Nagai M, et al., Neuronal splicing of the unmethylated histone H3K4 reader, PHF21A, prevents excessive synaptogenesis. J Biol Chem. 2024 Nov;300(11):107881
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory