Kpna6 MGI Mouse Gene Detail - MGI:1100836 - karyopherin subunit alpha 6

Symbol

Kpna6
Name

karyopherin subunit alpha 6
Synonyms

importin alpha 7, IPOA7, NPI-2

Feature Type

protein coding gene
IDs

MGI:1100836
NCBI Gene: 16650
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:129537773-129566560 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 63.28 cM, cytoband D2.3
Mapping Data

2 experiments

SNPs within 2kb

200 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1100836	protein coding gene	Chr4:129537772-129566560 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028836	protein coding gene	Chr4:131581318-131614970 (-)
A/J	MGP_AJ_G0028795	protein coding gene	Chr4:126320870-126352449 (-)
AKR/J	MGP_AKRJ_G0028748	protein coding gene	Chr4:129844004-129877351 (-)
BALB/cJ	MGP_BALBcJ_G0028818	protein coding gene	Chr4:126928396-126959522 (-)
C3H/HeJ	MGP_C3HHeJ_G0028532	protein coding gene	Chr4:129897535-129938677 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029260	protein coding gene	Chr4:136527588-136558081 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026532	protein coding gene	Chr4:119451792-119483512 (-)
CAST/EiJ	MGP_CASTEiJ_G0027964	protein coding gene	Chr4:128086806-128119067 (-)
CBA/J	MGP_CBAJ_G0028498	protein coding gene	Chr4:139945129-139977036 (-)
DBA/2J	MGP_DBA2J_G0028647	protein coding gene	Chr4:126757055-126788771 (-)
FVB/NJ	MGP_FVBNJ_G0028614	protein coding gene	Chr4:125513519-125545335 (-)
LP/J	MGP_LPJ_G0028748	protein coding gene	Chr4:131888637-131919817 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028640	protein coding gene	Chr4:144727345-144759295 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029298	protein coding gene	Chr4:130213414-130244629 (-)
PWK/PhJ	MGP_PWKPhJ_G0027686	protein coding gene	Chr4:123359410-123388961 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027512	protein coding gene	Chr4:126081122-126115126 (-)
WSB/EiJ	MGP_WSBEiJ_G0028045	protein coding gene	Chr4:130341637-130373481 (-)

Human Ortholog

KPNA6, karyopherin subunit alpha 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KPNA6, karyopherin subunit alpha 6
Synonyms

IPOA7
Links

HGNC:6399

NCBI Gene ID: 23633

neXtProt AC: NX_O60684

UniProt: O60684
Chr Location

1p35.2; chr1:32108056-32176563 (+) GRCh38

MGI Vertebrate Homology

Kpna6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KPNA6
Protein SuperFamily

Importin_alpha
Gene Tree

Kpna6

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Phenotype Summary

32 phenotypes from 4 alleles in 7 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Chemically induced (ENU)

2
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

17
Radiation induced

1
Targeted

6
Genomic Mutations

4 involving Kpna6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Female mice homozygous for a null mutation are infertile and show a block in zygotic genome activation. In male mice, homozygous deficiency results in multiple defects in both germ cells and Sertoli cells culminating in oligozoospermia.

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All GO Annotations

26
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

756
Tissues

22
cDNA Data

153
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KPNA6

Xenbase kpna6

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All Sequences

50
RefSeq

4
UniProt

4
CCDS

CCDS18701.1

Ensembl

ENSMUSG00000003731 (Evidence)
NCBI Gene

16650

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003731	Ensembl Gene Model \| MGI Sequence Detail	28788	C57BL/6J	± kb
transcript	ENSMUST00000102590	Ensembl \| MGI Sequence Detail	5710	Not Applicable
polypeptide	ENSMUSP00000099650	Ensembl \| MGI Sequence Detail	536	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009437 importin subunit alpha-7

(term hierarchy)
InterPro Domains

IPR000225 Armadillo

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR032413 Atypical Arm repeat

IPR002652 Importin-alpha, importin-beta-binding domain

IPR036975 Importin-alpha, importin-beta-binding domain superfamily

IPR024931 Importin subunit alpha
GlyGen

O35345 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 155

cDNA 153

Primer pair 2

Microarray probesets 4

Summaries

All 57

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 26
Earliest

J:43573 Tsuji L, et al., Identification of novel homologues of mouse importin alpha, the alpha subunit of the nuclear pore-targeting complex, and their tissue-specific expression. FEBS Lett. 1997 Oct 13;416(1):30-4
Latest

J:311959 Liu N, et al., Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis. Development. 2021 Oct 1;148(19):dev198374

TSS for Kpna6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43554	Chr4:129566575-129566586 (-)	-21 bp
Tssr43553	Chr4:129566505-129566567 (-)	24 bp
Tssr43552	Chr4:129566490-129566501 (-)	64 bp
Tssr43551	Chr4:129556235-129556278 (-)	10,303 bp
Tssr43550	Chr4:129541284-129541311 (-)	25,262 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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