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Kpna4 Gene Detail
Summary
  • Symbol
    Kpna4
  • Name
    karyopherin subunit alpha 4
  • Synonyms
    1110058D08Rik, importin alpha 3, IPOA3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100848
    NCBI Gene: 16649
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:68979554-69034425 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 32.18 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1010 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100848
 protein coding gene Chr3:68974482-69034446 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027293
 protein coding gene Chr3:68293499-68355943 (-)
A/J MGP_AJ_G0027255
 protein coding gene Chr3:66255414-66315043 (-)
AKR/J MGP_AKRJ_G0027223
 protein coding gene Chr3:67673905-67733524 (-)
BALB/cJ MGP_BALBcJ_G0027266
 protein coding gene Chr3:66137083-66199291 (-)
C3H/HeJ MGP_C3HHeJ_G0027010
 protein coding gene Chr3:67916071-67976931 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027712
 protein coding gene Chr3:70842637-70907090 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025065
 protein coding gene Chr3:62528703-62593365 (-)
CAST/EiJ MGP_CASTEiJ_G0026457
 protein coding gene Chr3:67868014-67930342 (-)
CBA/J MGP_CBAJ_G0026985
 protein coding gene Chr3:73030371-73097740 (-)
DBA/2J MGP_DBA2J_G0027121
 protein coding gene Chr3:65762884-65822699 (-)
FVB/NJ MGP_FVBNJ_G0027089
 protein coding gene Chr3:64382654-64442607 (-)
LP/J MGP_LPJ_G0027229
 protein coding gene Chr3:69226187-69285828 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027108
 protein coding gene Chr3:77643797-77715702 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027770
 protein coding gene Chr3:67563833-67623604 (-)
PWK/PhJ MGP_PWKPhJ_G0026191
 protein coding gene Chr3:65489792-65551433 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026007
 protein coding gene Chr3:66673858-66734685 (-)
WSB/EiJ MGP_WSBEiJ_G0026535
 protein coding gene Chr3:67717624-67779115 (-)



Homology
more
  • Human Ortholog
    KPNA4, karyopherin subunit alpha 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KPNA4, karyopherin subunit alpha 4
  • Synonyms
    IPOA3, QIP1, SRP3
  • Links
    NCBI Gene ID: 3840
    neXtProt AC: NX_O00629
    UniProt: O00629

  • Chr Location
    3q25.33; chr3:160495007-160565571 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced male fertility. Sperm exhibit abnormal head morphologies, flagella with multiple axonemes, and malformed axoneme structures, and impaired acrosome reaction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    827
  • Tissues
    110
  • cDNA Data
    93
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16649 NCBI Gene Model | MGI Sequence Detail 54872 C57BL/6J ±  kb
    transcript NM_008467 RefSeq | MGI Sequence Detail 3726 C57BL/6  
    polypeptide O35343 UniProt | EBI | MGI Sequence Detail 521 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 93
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1926016
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:43573 Tsuji L, et al., Identification of novel homologues of mouse importin alpha, the alpha subunit of the nuclear pore-targeting complex, and their tissue-specific expression. FEBS Lett. 1997 Oct 13;416(1):30-4
    • Latest
      J:354982 Sakurai K, et al., Importin alpha4 deficiency induces psychiatric disorder-related behavioral deficits and neuroinflammation in mice. Transl Psychiatry. 2024 Oct 8;14(1):426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory