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Mras Gene Detail
Summary
  • Symbol
    Mras
  • Name
    muscle and microspikes RAS
  • Synonyms
    2900078C09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100856
    NCBI Gene: 17532
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:99267473-99319434 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 51.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1481 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100856
 protein coding gene Chr9:99267473-99319505 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035169
 protein coding gene Chr9:100753924-100808139 (-)
A/J MGP_AJ_G0035150
 protein coding gene Chr9:97194542-97247043 (-)
AKR/J MGP_AKRJ_G0035082
 protein coding gene Chr9:99569931-99621754 (-)
BALB/cJ MGP_BALBcJ_G0035143
 protein coding gene Chr9:96877152-96929216 (-)
C3H/HeJ MGP_C3HHeJ_G0034853
 protein coding gene Chr9:99958187-100010827 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035663
 protein coding gene Chr9:103636137-103692572 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032562
 protein coding gene Chr9:94934121-94985695 (-)
CAST/EiJ MGP_CASTEiJ_G0034164
 protein coding gene Chr9:99777838-99836373 (-)
CBA/J MGP_CBAJ_G0034821
 protein coding gene Chr9:107189197-107243527 (-)
DBA/2J MGP_DBA2J_G0034983
 protein coding gene Chr9:96707006-96759317 (-)
FVB/NJ MGP_FVBNJ_G0034931
 protein coding gene Chr9:95525377-95579237 (-)
LP/J MGP_LPJ_G0035059
 protein coding gene Chr9:100998976-101052450 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034970
 protein coding gene Chr9:109106746-109164669 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035685
 protein coding gene Chr9:99816084-99870547 (-)
PWK/PhJ MGP_PWKPhJ_G0033871
 protein coding gene Chr9:96924052-96976819 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033706
 protein coding gene Chr9:99876997-99934988 (-)
WSB/EiJ MGP_WSBEiJ_G0034284
 protein coding gene Chr9:99689676-99744269 (-)



Homology
more
  • Human Ortholog
    MRAS, muscle RAS oncogene homolog
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRAS, muscle RAS oncogene homolog
  • Synonyms
    M-RAs, NS11, R-RAS3, RRAS3
  • Links
    NCBI Gene ID: 22808
    neXtProt AC: NX_O14807
    UniProt: O14807

  • Chr Location
    3q22.3; chr3:138347648-138405535 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MRAS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an insertional mutation that inactivates the gene exhibit a decreased mean percentage of peripheral blood B cells but no other evidence of morphological or neurological defects; mutant astrocytes display normal responsiveness to different trophic factors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    27
  • cDNA Data
    50
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032470 Ensembl Gene Model | MGI Sequence Detail 51962 C57BL/6J ±  kb
    transcript ENSMUST00000119472 Ensembl | MGI Sequence Detail 1190 Not Applicable  
    polypeptide ENSMUSP00000112407 Ensembl | MGI Sequence Detail 208 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 51

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920303, MGI:2143025
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:36917 Kogerman P, et al., CD44 protein levels and its biological activity are regulated in Balb/c 3T3 fibroblasts by serum factors and by transformation with the ras but not with the sis oncogene. J Cell Physiol. 1996 Nov;169(2):341-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory