Asic2 MGI Mouse Gene Detail - MGI:1100867 - acid-sensing ion channel 2

Symbol

Asic2
Name

acid-sensing ion channel 2
Synonyms

Accn1, BNaC1a, BNC1, Mdeg

Feature Type

protein coding gene
IDs

MGI:1100867
NCBI Gene: 11418
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:80770989-81859222 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 48.43 cM
Mapping Data

2 experiments

SNPs within 2kb

30825 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1100867	protein coding gene	Chr11:80770989-81859283 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018818	protein coding gene	Chr11:82066272-83206063 (-)
A/J	MGP_AJ_G0018785	protein coding gene	Chr11:78919061-80007593 (-)
AKR/J	MGP_AKRJ_G0018755	protein coding gene	Chr11:81263889-82401362 (-)
BALB/cJ	MGP_BALBcJ_G0018758	protein coding gene	Chr11:79313572-80405242 (-)
C3H/HeJ	MGP_C3HHeJ_G0018572	protein coding gene	Chr11:81344638-82455472 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019210	protein coding gene	Chr11:84569351-85708868 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016844	protein coding gene	Chr11:75841652-76979011 (-)
CAST/EiJ	MGP_CASTEiJ_G0018127	protein coding gene	Chr11:81831643-83006256 (-)
CBA/J	MGP_CBAJ_G0018543	protein coding gene	Chr11:88289256-89466971 (-)
DBA/2J	MGP_DBA2J_G0018651	protein coding gene	Chr11:78473028-79571290 (-)
FVB/NJ	MGP_FVBNJ_G0018640	protein coding gene	Chr11:78033986-79120119 (-)
LP/J	MGP_LPJ_G0018721	protein coding gene	Chr11:82590562-83734880 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018667	protein coding gene	Chr11:88541318-89654076 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019250	protein coding gene	Chr11:81556946-82672654 (-)
PWK/PhJ	MGP_PWKPhJ_G0017897	protein coding gene	Chr11:79290533-80395474 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017688	protein coding gene	Chr11:81153352-82285034 (-)
WSB/EiJ	MGP_WSBEiJ_G0018179	protein coding gene	Chr11:81393890-82540360 (-)

Human Ortholog

ASIC2, acid sensing ion channel subunit 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ASIC2, acid sensing ion channel subunit 2
Synonyms

ACCN, ACCN1, ASIC2a, BNaC1, BNC1, hBNaC1, MDEG
Links

HGNC:99

NCBI Gene ID: 40

neXtProt AC: NX_Q16515

UniProt: Q16515
Chr Location

17q11.2-q12; chr17:33013087-34174964 (-) GRCh38

MGI Vertebrate Homology

Asic2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ASIC2
Gene Tree

Asic2

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Phenotype Summary

13 phenotypes from 3 alleles in 4 genetic backgrounds
57 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

6
Targeted

4
Transgenic

2
Genomic Mutations

2 involving Asic2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased mechanoreceptor and spiral ganglion electrophysiology and decreased pressure-induced blood vessel constriction. Mice homozygous for a different knock-out allele exhibit retinal degeneration and abnormal eye electrophysiology.

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All GO Annotations

57
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

854
Tissues

39
cDNA Data

12
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase asic2

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All Sequences

62
RefSeq

6
UniProt

4
CCDS

CCDS25137.1, CCDS36243.1

Ensembl

ENSMUSG00000020704 (Evidence)
NCBI Gene

11418

			Length	Strain/Species	Flank
genomic	11418	NCBI Gene Model \| MGI Sequence Detail	1088234	C57BL/6J	± kb
transcript	NM_007384	RefSeq \| MGI Sequence Detail	3024	ZRU/MplStud
polypeptide	Q925H0	UniProt \| EBI \| MGI Sequence Detail	512	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003614 acid-sensing ion channel 2

(term hierarchy)
InterPro Domains

IPR001873 Epithelial sodium channel

IPR004724 Epithelial sodium channel, chordates

IPR020903 Epithelial sodium channel, conserved site
GlyGen

Q925H0 3 sites, 1 N-linked glycan (1 site)

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 3

Summaries

All 94

Developmental Gene Expression 6

Gene Ontology 18

Phenotypes 57
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:353823 Hamby M, et al., Mice lacking ASIC2 and betaENaC are protected from high-fat-diet-induced metabolic syndrome. Front Endocrinol (Lausanne). 2024;15:1449344

TSS for Asic2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109563	Chr11:81859241-81859252 (-)	-25 bp
Tssr109561	Chr11:81758524-81758535 (-)	100,692 bp
Tssr109560	Chr11:81749549-81749554 (-)	109,670 bp
Tssr109559	Chr11:81483940-81483944 (-)	375,280 bp
Tssr109557	Chr11:81044531-81044545 (-)	814,684 bp
Tssr109556	Chr11:81044471-81044488 (-)	814,742 bp
Tssr109555	Chr11:81044429-81044468 (-)	814,773 bp
Tssr109554	Chr11:80966578-80966579 (-)	892,643 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24