Plagl1 MGI Mouse Gene Detail - MGI:1100874 - pleiomorphic adenoma gene-like 1

Symbol

Plagl1
Name

pleiomorphic adenoma gene-like 1
Synonyms

Zac1

Feature Type

protein coding gene
IDs

MGI:1100874
NCBI Gene: 22634
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr10:12966576-13007438 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 4.72 cM
Mapping Data

1 experiment

SNPs within 2kb

1037 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1100874	protein coding gene	Chr10:12936248-13007438 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017018	protein coding gene	Chr10:10454066-10526599 (+)
A/J	MGP_AJ_G0016996	protein coding gene	Chr10:10054842-10132023 (+)
AKR/J	MGP_AKRJ_G0016960	protein coding gene	Chr10:10287069-10359007 (+)
BALB/cJ	MGP_BALBcJ_G0016954	protein coding gene	Chr10:10054741-10130227 (+)
C3H/HeJ	MGP_C3HHeJ_G0016779	protein coding gene	Chr10:10448240-10519800 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017416	protein coding gene	Chr10:10734243-10807756 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015121	protein coding gene	Chr10:9340047-9410303 (+)
CAST/EiJ	MGP_CASTEiJ_G0016361	protein coding gene	Chr10:10304479-10379136 (+)
CBA/J	MGP_CBAJ_G0016751	protein coding gene	Chr10:11132202-11211825 (+)
DBA/2J	MGP_DBA2J_G0016859	protein coding gene	Chr10:9965773-10037024 (+)
FVB/NJ	MGP_FVBNJ_G0016854	protein coding gene	Chr10:9805681-9877266 (+)
LP/J	MGP_LPJ_G0016934	protein coding gene	Chr10:10312431-10385245 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016884	protein coding gene	Chr10:11044350-11119495 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017454	protein coding gene	Chr10:10173026-10249398 (+)
PWK/PhJ	MGP_PWKPhJ_G0016146	protein coding gene	Chr10:9847187-9919409 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015929	protein coding gene	Chr10:10308290-10415717 (+)
WSB/EiJ	MGP_WSBEiJ_G0016423	protein coding gene	Chr10:10219706-10292900 (+)

Human Ortholog

PLAGL1, PLAG1 like zinc finger 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLAGL1, PLAG1 like zinc finger 1
Synonyms

LOT1, ZAC, ZAC1
Links

HGNC:9046

NCBI Gene ID: 5325

neXtProt AC: NX_Q9UM63

UniProt: Q9UM63
Chr Location

6q24.2; chr6:143940300-144064599 (-) GRCh38

MGI Vertebrate Homology

Plagl1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PLAGL1
Gene Tree

Plagl1

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Phenotype Summary

23 phenotypes from 2 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

8
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit significantly reduced birth weights. Heterozygous mice with a paternal copy of the null allele show reduced fetal and birth weights, altered ossification, dyspnea and background-dependent neonatal lethality, as well as wrinkled skin and curly tails with 30% penetrance.

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1499
Tissues

410
cDNA Data

70
Literature Summary

55

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

89
RefSeq

8
UniProt

10
CCDS

CCDS48501.1, CCDS87960.1

Ensembl

ENSMUSG00000019817 (Evidence)
NCBI Gene

22634

			Length	Strain/Species	Flank
genomic	22634	NCBI Gene Model \| MGI Sequence Detail	40863	C57BL/6J	± kb
transcript	NM_009538	RefSeq \| MGI Sequence Detail	5235	ZRU/MplStud
polypeptide	NP_033564	RefSeq \| MGI Sequence Detail	704	ZRU/MplStud

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UniProt

10 Sequences
InterPro Domains

IPR050636 C2H2-type zinc finger domain-containing protein

IPR050331 Zinc finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 86

cDNA 70

Primer pair 11

Other 5

Microarray probesets 5

Summaries

All 96

Developmental Gene Expression 55

Gene Ontology 5

Phenotypes 12
Earliest

J:40765 Spengler D, et al., Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J. 1997 May 15;16(10):2814-25
Latest

J:349865 Carabana C, et al., Spatially distinct epithelial and mesenchymal cell subsets along progressive lineage restriction in the branching embryonic mammary gland. EMBO J. 2024 Jun;43(12):2308-2336

TSS for Plagl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92381	Chr10:12966569-12966587 (+)	2 bp
Tssr92382	Chr10:12984562-12984566 (+)	17,988 bp
Tssr92383	Chr10:12985134-12985137 (+)	18,560 bp
Tssr92384	Chr10:13000695-13000709 (+)	34,126 bp
Tssr92385	Chr10:13004761-13004795 (+)	38,202 bp
Tssr92386	Chr10:13005319-13005328 (+)	38,748 bp
Tssr92387	Chr10:13005569-13005600 (+)	39,009 bp
Tssr92388	Chr10:13005767-13005803 (+)	39,209 bp
Tssr92389	Chr10:13006060-13006081 (+)	39,495 bp
Tssr92390	Chr10:13006337-13006383 (+)	39,784 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24