Ece2 MGI Mouse Gene Detail - MGI:1101356 - endothelin converting enzyme 2

Symbol

Ece2
Name

endothelin converting enzyme 2
Synonyms

1810009K13Rik, 6330509A19Rik, 9630025D12Rik

Feature Type

protein coding gene
IDs

MGI:1101356
NCBI Gene: 107522
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr16:20448601-20464665 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 12.48 cM, cytoband B1
Mapping Data

3 experiments

SNPs within 2kb

383 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1101356	protein coding gene	Chr16:20448578-20465235 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022648	protein coding gene	Chr16:17949016-17985490 (+)
A/J	MGP_AJ_G0022610	protein coding gene	Chr16:17086071-17120868 (+)
AKR/J	MGP_AKRJ_G0022585	protein coding gene	Chr16:17732730-17767521 (+)
BALB/cJ	MGP_BALBcJ_G0022614	protein coding gene	Chr16:17243741-17278800 (+)
C3H/HeJ	MGP_C3HHeJ_G0022379	protein coding gene	Chr16:17898970-17933883 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023065	protein coding gene	Chr16:18296325-18333136 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020582	protein coding gene	Chr16:17771679-17809196 (+)
CAST/EiJ	MGP_CASTEiJ_G0021909	protein coding gene	Chr16:17873073-17907944 (+)
CBA/J	MGP_CBAJ_G0022351	protein coding gene	Chr16:19049325-19087896 (+)
DBA/2J	MGP_DBA2J_G0022483	protein coding gene	Chr16:17012364-17047649 (+)
FVB/NJ	MGP_FVBNJ_G0022458	protein coding gene	Chr16:17047865-17084456 (+)
LP/J	MGP_LPJ_G0022550	protein coding gene	Chr16:17680838-17716798 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022478	protein coding gene	Chr16:18729545-18768099 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023076	protein coding gene	Chr16:17698006-17737569 (+)
PWK/PhJ	MGP_PWKPhJ_G0021650	protein coding gene	Chr16:17275394-17311505 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021479	protein coding gene	Chr16:17496358-17541080 (+)
WSB/EiJ	MGP_WSBEiJ_G0021953	protein coding gene	Chr16:17691946-17732409 (+)

Human Ortholog

ECE2, endothelin converting enzyme 2

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ECE2, endothelin converting enzyme 2
Synonyms

EEF1AKMT4
Links

HGNC:13275

NCBI Gene ID: 9718

neXtProt AC: NX_P0DPD6, NX_P0DPD8

UniProt: P0DPD6
Chr Location

3q27.1; chr3:184276011-184293031 (+) GRCh38

Human Ortholog

EEF1AKMT4-ECE2, EEF1AKMT4-ECE2 readthrough
Synonyms

ECE-2, ECE2
Links

HGNC:53615

NCBI Gene ID: 110599583

neXtProt AC: NX_P0DPD6, NX_P0DPD8

UniProt: P0DPD8
Chr Location

3q27.1; chr3:184249672-184293031 (+) GRCh38

MGI Vertebrate Homology

Ece2 stringent orthology
2 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ECE2, EEF1AKMT4-ECE2
Gene Tree

Ece2

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotypes from multigenic genotypes
2 images
11 phenotype references

All Mutations and Alleles

3
Endonuclease-mediated

1
Gene trapped

1
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available

Homozygous mutant mice develop normally, are viable and healthy, and exhibit normal fertility in both sexes, as well as a normal life span.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

758
Tissues

37
cDNA Data

34
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ece2

ZFIN ece2b

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All Sequences

48
RefSeq

4
CCDS

CCDS28052.1, CCDS49796.1

Ensembl

ENSMUSG00000022842 (Evidence)
NCBI Gene

107522

			Length	Strain/Species	Flank
genomic	107522	NCBI Gene Model \| MGI Sequence Detail	16065	C57BL/6J	± kb
transcript	NM_139293	RefSeq \| MGI Sequence Detail	3129	C57BL/6
polypeptide	NP_647454	RefSeq \| MGI Sequence Detail	763	C57BL/6

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Protein Ontology

PR:000006875 endothelin-converting enzyme 2

(term hierarchy)

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All nucleic 35

cDNA 34

Primer pair 1

Microarray probesets 6

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MGI:1913525, MGI:2146683, MGI:2444026

Summaries

All 42

Developmental Gene Expression 3

Diseases 1

Gene Ontology 6

Phenotypes 11
Earliest

J:42648 Emoto N, et al., Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. J Biol Chem. 1995 Jun 23;270(25):15262-8
Latest

J:342802 Wang N, et al., Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures. Neuron. 2022 Oct 19;110(20):3318-3338.e9

TSS for Ece2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137457	Chr16:20448549-20448587 (+)	-33 bp
Tssr137458	Chr16:20448592-20448644 (+)	17 bp
Tssr137459	Chr16:20448722-20448733 (+)	127 bp
Tssr137460	Chr16:20448734-20448756 (+)	144 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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