Bmx MGI Mouse Gene Detail - MGI:1101778 - BMX non-receptor tyrosine kinase

Symbol

Bmx
Name

BMX non-receptor tyrosine kinase
Synonyms

Etk, Etk/Bmx, Tyro8

Feature Type

protein coding gene
IDs

MGI:1101778
NCBI Gene: 12169
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

ChrX:162975838-163041189 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 76.12 cM, cytoband F
Mapping Data

3 experiments

SNPs within 2kb

1506 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1101778	protein coding gene	ChrX:162975838-163041189 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036253	protein coding gene	ChrX:162274261-162343576 (-)
A/J	MGP_AJ_G0036223	protein coding gene	ChrX:161454208-161520702 (-)
AKR/J	MGP_AKRJ_G0036151	protein coding gene	ChrX:166633689-166708365 (-)
BALB/cJ	MGP_BALBcJ_G0036216	protein coding gene	ChrX:159449169-159515776 (-)
C3H/HeJ	MGP_C3HHeJ_G0035923	protein coding gene	ChrX:162620743-162686775 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036739	protein coding gene	ChrX:167025275-167097216 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033559	protein coding gene	ChrX:152497564-152560311 (-)
CAST/EiJ	MGP_CASTEiJ_G0035211	protein coding gene	ChrX:141608097-141679356 (-)
CBA/J	MGP_CBAJ_G0035897	protein coding gene	ChrX:171868791-171936156 (-)
DBA/2J	MGP_DBA2J_G0036063	protein coding gene	ChrX:160335586-160398079 (-)
FVB/NJ	MGP_FVBNJ_G0035995	protein coding gene	ChrX:159467574-159535564 (-)
LP/J	MGP_LPJ_G0036148	protein coding gene	ChrX:163409958-163475711 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0036027	protein coding gene	ChrX:180552875-180630517 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036778	protein coding gene	ChrX:161760904-161829593 (-)
PWK/PhJ	MGP_PWKPhJ_G0034909	protein coding gene	ChrX:138381418-138447932 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034730	protein coding gene	ChrX:142107571-142177939 (-)
WSB/EiJ	MGP_WSBEiJ_G0035346	protein coding gene	ChrX:159729770-159798208 (-)

Human Ortholog

BMX, BMX non-receptor tyrosine kinase

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BMX, BMX non-receptor tyrosine kinase
Synonyms

ETK, PSCTK2, PSCTK3
Links

HGNC:1079

NCBI Gene ID: 660

neXtProt AC: NX_P51813

UniProt: P51813
Chr Location

Xp22.2; chrX:15464246-15556529 (+) GRCh38

MGI Vertebrate Homology

Bmx stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: BMX
Gene Tree

Bmx

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Phenotype Summary

3 phenotypes from 2 alleles in 3 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

6
Gene trapped

1
Targeted

5
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null mutation are fertile and have a normal life span but are protected from arthritis in a passive transfer model.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

938
Tissues

142
cDNA Data

20
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

4
CCDS

CCDS30519.2

Ensembl

ENSMUSG00000031377 (Evidence)
NCBI Gene

12169

			Length	Strain/Species	Flank
genomic	12169	NCBI Gene Model \| MGI Sequence Detail	65352	C57BL/6J	± kb
transcript	NM_009759	RefSeq \| MGI Sequence Detail	3005	C57BL/6
polypeptide	P97504	UniProt \| EBI \| MGI Sequence Detail	651	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000002200 cytoplasmic tyrosine-protein kinase BMX

(term hierarchy)
EC

2.7.10.2
InterPro Domains

IPR035875 BMX, SH2 domain

IPR050198 Non-receptor tyrosine kinases involved in cell signaling

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR001562 Zinc finger, Btk motif
GlyGen

P97504 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 25

Genomic 1

cDNA 20

Primer pair 3

Other 1

Microarray probesets 3

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MGD-MRK-38318, MGI:109273

Summaries

All 56

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 22
Earliest

J:36874 Rinke de Wit TF, et al., Expression of tyrosine kinase gene in mouse thymic stromal cells. Int Immunol. 1996 Nov;8(11):1787-95
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bmx:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164538	ChrX:163041816-163041821 (-)	-630 bp
Tssr164537	ChrX:163041182-163041195 (-)	0 bp
Tssr164536	ChrX:163033372-163033378 (-)	7,814 bp
Tssr164535	ChrX:163029726-163029741 (-)	11,455 bp
Tssr164534	ChrX:163012172-163012174 (-)	29,016 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24