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Thbs4 Gene Detail
Summary
  • Symbol
    Thbs4
  • Name
    thrombospondin 4
  • Synonyms
    TSP-4, TSP4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101779
    NCBI Gene: 21828
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:92888098-92931326 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 47.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1344 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101779
 protein coding gene Chr13:92888094-92931326 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020820
 protein coding gene Chr13:94078433-94123083 (-)
A/J MGP_AJ_G0020774
 protein coding gene Chr13:90584075-90627523 (-)
AKR/J MGP_AKRJ_G0020747
 protein coding gene Chr13:93321304-93365373 (-)
BALB/cJ MGP_BALBcJ_G0020770
 protein coding gene Chr13:91226439-91269805 (-)
C3H/HeJ MGP_C3HHeJ_G0020564
 protein coding gene Chr13:93036623-93080796 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021207
 protein coding gene Chr13:96942490-96986572 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018774
 protein coding gene Chr13:86505469-86548941 (-)
CAST/EiJ MGP_CASTEiJ_G0020083
 protein coding gene Chr13:92291842-92339332 (-)
CBA/J MGP_CBAJ_G0020523
 protein coding gene Chr13:100765216-100815102 (-)
DBA/2J MGP_DBA2J_G0020648
 protein coding gene Chr13:90347602-90390827 (-)
FVB/NJ MGP_FVBNJ_G0020628
 protein coding gene Chr13:89163227-89207406 (-)
LP/J MGP_LPJ_G0020721
 protein coding gene Chr13:94191759-94236022 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020657
 protein coding gene Chr13:101273973-101318879 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021247
 protein coding gene Chr13:92729003-92772160 (-)
PWK/PhJ MGP_PWKPhJ_G0019835
 protein coding gene Chr13:89084369-89127725 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019659
 protein coding gene Chr13:88996026-89041126 (-)
WSB/EiJ MGP_WSBEiJ_G0020140
 protein coding gene Chr13:93214215-93261545 (-)



Homology
more
  • Human Ortholog
    THBS4, thrombospondin 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THBS4, thrombospondin 4
  • Synonyms
    TSP-4, TSP4
  • Links
    NCBI Gene ID: 7060
    neXtProt AC: NX_P35443
    UniProt: P35443

  • Chr Location
    5q14.1; chr5:79991311-80083287 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit increased sensitivity to cardiac pressure overload, including increased hypertrophy, decreased ejection fraction, decreased microvessel number, increased extracellular matrix deposition and increased fibrosis. Homozygous KO leads to impaired wound healing and delayed retinal vasculature development and affects macrophage differentiation. Homozygosity for the p.A389P mutation leads to enhanced wound healing and accelerated retinal vasculature development and affects macrophage differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1033
  • Tissues
    80
  • cDNA Data
    35
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021702 Ensembl Gene Model | MGI Sequence Detail 43229 C57BL/6J ±  kb
    transcript ENSMUST00000022213 Ensembl | MGI Sequence Detail 3198 Not Applicable  
    polypeptide ENSMUSP00000022213 Ensembl | MGI Sequence Detail 963 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000000132 thrombospondin-4
      (term hierarchy)
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR024665 Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
      IPR046970 Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain superfamily
      IPR008859 Thrombospondin, C-terminal
      IPR048287 Thrombospondin-like, N-terminal domain
      IPR003367 Thrombospondin, type 3-like repeat
      IPR017897 Thrombospondin, type 3 repeat
      IPR028974 TSP type-3 repeat
    • GlyGen
      Q9Z1T2 3 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 37
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 20
      Gene Ontology 10
      Phenotypes 36
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:354224 Van Wauwe J, et al., PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates. Life Sci Alliance. 2024 Dec;7(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory