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Tgif1 Gene Detail
Summary
  • Symbol
    Tgif1
  • Name
    TGFB-induced factor homeobox 1
  • Synonyms
    Tgif
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194497
    NCBI Gene: 21815
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:71151200-71160527 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 41.87 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    230 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194497
 protein coding gene Chr17:71151200-71160541 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024000
 protein coding gene Chr17:73253427-73263737 (-)
A/J MGP_AJ_G0023958
 protein coding gene Chr17:71021382-71030698 (-)
AKR/J MGP_AKRJ_G0023927
 protein coding gene Chr17:71997468-72006797 (-)
BALB/cJ MGP_BALBcJ_G0023959
 protein coding gene Chr17:70947662-70956991 (-)
C3H/HeJ MGP_C3HHeJ_G0023723
 protein coding gene Chr17:72950068-72959385 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024405
 protein coding gene Chr17:75914509-75923875 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021851
 protein coding gene Chr17:66807021-66816376 (-)
CAST/EiJ MGP_CASTEiJ_G0023204
 protein coding gene Chr17:73374627-73383933 (-)
CBA/J MGP_CBAJ_G0023698
 protein coding gene Chr17:79083678-79093023 (-)
DBA/2J MGP_DBA2J_G0023827
 protein coding gene Chr17:69710626-69719938 (-)
FVB/NJ MGP_FVBNJ_G0023793
 protein coding gene Chr17:69178846-69189139 (-)
LP/J MGP_LPJ_G0023909
 protein coding gene Chr17:74006084-74015463 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023821
 protein coding gene Chr17:78975232-78986278 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024449
 protein coding gene Chr17:72516601-72525928 (-)
PWK/PhJ MGP_PWKPhJ_G0022950
 protein coding gene Chr17:69014507-69023867 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022761
 protein coding gene Chr17:69228548-69237891 (-)
WSB/EiJ MGP_WSBEiJ_G0023271
 protein coding gene Chr17:73318700-73327999 (-)



Homology
more
  • Human Ortholog
    TGIF1, TGFB induced factor homeobox 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGIF1, TGFB induced factor homeobox 1
  • Synonyms
    HPE4, TGIF
  • Links
    NCBI Gene ID: 7050
    neXtProt AC: NX_Q15583
    UniProt: Q15583

  • Chr Location
    18p11.31; chr18:3411608-3459978 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tgif1 mouse models; 2 with human TGIF1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
 View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 6 alleles in 8 genetic backgrounds
    36 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display normal growth, behavior and fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1051
  • Tissues
    199
  • cDNA Data
    174
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21815 NCBI Gene Model | MGI Sequence Detail 9328 C57BL/6J ±  kb
    transcript NM_001424962 RefSeq | MGI Sequence Detail 1912 C57BL/6  
    polypeptide P70284 UniProt | EBI | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 183
      cDNA 174
      Primer pair 8
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146782, MGI:2146872
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 27
      Diseases 2
      Gene Ontology 11
      Phenotypes 37
    • Earliest
      J:32973 Bertolino E, et al., Expression of a novel murine homeobox gene in the developing cerebellar external granular layer during its proliferation. Dev Dyn. 1996 Apr;205(4):410-20
    • Latest
      J:346342 Taipaleenmaki H, et al., Antagonizing microRNA-19a/b augments PTH anabolic action and restores bone mass in osteoporosis in mice. EMBO Mol Med. 2022 Nov 8;14(11):e13617
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory