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Kcnj10 Gene Detail
Summary
  • Symbol
    Kcnj10
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 10
  • Synonyms
    BIR10, BIRK-1, Kir1.2, Kir4.1, Kir4.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194504
    NCBI Gene: 16513
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:172168777-172201652 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 79.69 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    987 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194504
 protein coding gene Chr1:172168777-172201652 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016786
 protein coding gene Chr1:178201998-178236295 (+)
A/J MGP_AJ_G0016765
 protein coding gene Chr1:170907628-170941686 (+)
AKR/J MGP_AKRJ_G0016731
 protein coding gene Chr1:176071537-176104519 (+)
BALB/cJ MGP_BALBcJ_G0016726
 protein coding gene Chr1:171453728-171486930 (+)
C3H/HeJ MGP_C3HHeJ_G0016550
 protein coding gene Chr1:176645170-176678182 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017188
 protein coding gene Chr1:184116961-184153987 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014894
 protein coding gene Chr1:162610829-162644073 (+)
CAST/EiJ MGP_CASTEiJ_G0016130
 protein coding gene Chr1:176014792-176052199 (+)
CBA/J MGP_CBAJ_G0016524
 protein coding gene Chr1:190658978-190694943 (+)
DBA/2J MGP_DBA2J_G0016631
 protein coding gene Chr1:169844200-169877151 (+)
FVB/NJ MGP_FVBNJ_G0016628
 protein coding gene Chr1:168099691-168132586 (+)
LP/J MGP_LPJ_G0016702
 protein coding gene Chr1:179291240-179324248 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016655
 protein coding gene Chr1:197906679-197939646 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017224
 protein coding gene Chr1:175941065-175974973 (+)
PWK/PhJ MGP_PWKPhJ_G0015916
 protein coding gene Chr1:169222539-169255794 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015698
 protein coding gene Chr1:174892671-174924665 (+)
WSB/EiJ MGP_WSBEiJ_G0016192
 protein coding gene Chr1:176095446-176133412 (+)



Homology
more
  • Human Ortholog
    KCNJ10, potassium inwardly rectifying channel subfamily J member 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNJ10, potassium inwardly rectifying channel subfamily J member 10
  • Synonyms
    BIRK-10, KCNJ13-PEN, KIR1.2, KIR4.1, SESAME
  • Links
    NCBI Gene ID: 3766
    neXtProt AC: NX_P78508
    UniProt: P78508

  • Chr Location
    1q23.2; chr1:159998651-160070483 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Kcnj10 mouse models; 2 with human KCNJ10 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    78 phenotypes from 3 alleles in 4 genetic backgrounds
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice show increased input resistance and high depolarization of retinal Muller cells, loss of the endocochlear potential, motor coordination deficits and hindlimb paralysis, and a hypomyelination and spongiform vacuolation in the spinalcord associated with severe axonal pathology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    31
  • cDNA Data
    32
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16513 NCBI Gene Model | MGI Sequence Detail 32876 C57BL/6J ±  kb
    transcript NM_001039484 RefSeq | MGI Sequence Detail 5407 ZRU/MplStud  
    polypeptide Q9JM63 UniProt | EBI | MGI Sequence Detail 379 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000001979 ATP-sensitive inward rectifier potassium channel 10
      (term hierarchy)
    • InterPro Domains
      IPR014756 Immunoglobulin E-set
      IPR041647 Inward rectifier potassium channel, C-terminal
      IPR016449 Potassium channel, inwardly rectifying, Kir
      IPR003269 Potassium channel, inwardly rectifying, Kir1.2
      IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
      IPR040445 Potassium channel, inwardly rectifying, transmembrane domain
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 9
      cDNA 32
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 26
      Diseases 2
      Gene Ontology 18
      Phenotypes 51
    • Earliest
      J:44256 Tada Y, et al., Assignment of the glial inwardly rectifying potassium channel KAB-2/Kir4.1 (Kcnj10) gene to the distal region of mouse chromosome 1. Genomics. 1997 Nov 1;45(3):629-30
    • Latest
      J:351398 Peters C, et al., Voltage-Gated Ion Channels Are Transcriptional Targets of Sox10 during Oligodendrocyte Development. Cells. 2024 Jul 7;13(13)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory