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C1qbp Gene Detail
Summary
  • Symbol
    C1qbp
  • Name
    complement component 1, q subcomponent binding protein
  • Synonyms
    D11Wsu182e, HABP1, P32
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194505
    NCBI Gene: 12261
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70868672-70873852 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 43.21 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194505
 protein coding gene Chr11:70868662-70873852 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018620
 protein coding gene Chr11:71553322-71559714 (-)
A/J MGP_AJ_G0018588
 protein coding gene Chr11:68833840-68839050 (-)
AKR/J MGP_AKRJ_G0018557
 protein coding gene Chr11:70908316-70913518 (-)
BALB/cJ MGP_BALBcJ_G0018560
 protein coding gene Chr11:69144079-69149269 (-)
C3H/HeJ MGP_C3HHeJ_G0018373
 protein coding gene Chr11:70936164-70941357 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019011
 protein coding gene Chr11:73721469-73726659 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016656
 protein coding gene Chr11:65739254-65744715 (-)
CAST/EiJ MGP_CASTEiJ_G0017928
 protein coding gene Chr11:71214726-71219920 (-)
CBA/J MGP_CBAJ_G0018345
 protein coding gene Chr11:77041961-77049016 (-)
DBA/2J MGP_DBA2J_G0018455
 protein coding gene Chr11:68413752-68418989 (-)
FVB/NJ MGP_FVBNJ_G0018445
 protein coding gene Chr11:68056976-68062176 (-)
LP/J MGP_LPJ_G0018525
 protein coding gene Chr11:72133497-72139000 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018468
 protein coding gene Chr11:77583202-77588406 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019053
 protein coding gene Chr11:71166204-71171403 (-)
PWK/PhJ MGP_PWKPhJ_G0017702
 protein coding gene Chr11:69068025-69073359 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017492
 protein coding gene Chr11:70975502-70980696 (-)
WSB/EiJ MGP_WSBEiJ_G0017982
 protein coding gene Chr11:70829498-70836197 (-)



Homology
more
  • Human Ortholog
    C1QBP, complement C1q binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C1QBP, complement C1q binding protein
  • Synonyms
    COXPD33, GC1QBP, gC1qR, gC1Q-R, HABP1, p32, SF2AP32, SF2p32
  • Links
    NCBI Gene ID: 708
    neXtProt AC: NX_Q07021
    UniProt: Q07021

  • Chr Location
    17p13.2; chr17:5432777-5448830 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human C1QBP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality by E11.5 with poor development, small embryo size, pale and anemic organs, poor cellular proliferation and impaired mitochondrial electron transport chain function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    91
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    941
  • Tissues
    114
  • cDNA Data
    153
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12261 NCBI Gene Model | MGI Sequence Detail 5181 C57BL/6J ±  kb
    transcript NM_007573 RefSeq | MGI Sequence Detail 1177 ZRU/MplStud  
    polypeptide O35658 UniProt | EBI | MGI Sequence Detail 278 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004877 complement component 1 Q subcomponent-binding protein, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR003428 Mitochondrial glycoprotein
      IPR036561 Mitochondrial glycoprotein superfamily
    • GlyGen
      O35658 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 162
      Genomic 7
      cDNA 153
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36447, MGI:107870, MGI:2143969, MGI:2144060
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 31
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:353787 Gutierrez-Aguilar M, et al., Endogenous complement 1q binding protein (C1qbp) regulates mitochondrial permeability transition and post-myocardial infarction remodeling and dysfunction. J Mol Cell Cardiol. 2024 Aug 30;196:1-11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory