Ddost MGI Mouse Gene Detail - MGI:1194508 - dolichyl-di-phosphooligosaccharide-protein glycotransferase

Symbol

Ddost
Name

dolichyl-di-phosphooligosaccharide-protein glycotransferase

Feature Type

protein coding gene
IDs

MGI:1194508
NCBI Gene: 13200
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:138032049-138039930 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 70.13 cM, cytoband D3
Mapping Data

2 experiments

SNPs within 2kb

408 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1194508	protein coding gene	Chr4:138032041-138039939 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028993	protein coding gene	Chr4:141031708-141041039 (+)
A/J	MGP_AJ_G0028952	protein coding gene	Chr4:135005639-135013446 (+)
AKR/J	MGP_AKRJ_G0028904	protein coding gene	Chr4:138854928-138862798 (+)
BALB/cJ	MGP_BALBcJ_G0028976	protein coding gene	Chr4:135677529-135685324 (+)
C3H/HeJ	MGP_C3HHeJ_G0028690	protein coding gene	Chr4:139216772-139225846 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029417	protein coding gene	Chr4:146042743-146050561 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026688	protein coding gene	Chr4:127986508-127994342 (+)
CAST/EiJ	MGP_CASTEiJ_G0028122	protein coding gene	Chr4:137372804-137382359 (+)
CBA/J	MGP_CBAJ_G0028655	protein coding gene	Chr4:150200924-150208747 (+)
DBA/2J	MGP_DBA2J_G0028804	protein coding gene	Chr4:135382958-135390753 (+)
FVB/NJ	MGP_FVBNJ_G0028771	protein coding gene	Chr4:134402775-134410580 (+)
LP/J	MGP_LPJ_G0028903	protein coding gene	Chr4:141108804-141118164 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028797	protein coding gene	Chr4:154217463-154225285 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029455	protein coding gene	Chr4:139367438-139376482 (+)
PWK/PhJ	MGP_PWKPhJ_G0027843	protein coding gene	Chr4:132232747-132240698 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027668	protein coding gene	Chr4:135147099-135154919 (+)
WSB/EiJ	MGP_WSBEiJ_G0028200	protein coding gene	Chr4:139598519-139606340 (+)

Human Ortholog

DDOST, dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDOST, dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
Synonyms

AGER1, CDG1R, GATD6, OKSWcl45, OST, OST48, WBP1
Links

HGNC:2728

NCBI Gene ID: 1650

neXtProt AC: NX_P39656

UniProt: P39656
Chr Location

1p36.12; chr1:20651767-20661544 (-) GRCh38

MGI Vertebrate Homology

Ddost stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDOST
Gene Tree

Ddost

Diseases

1 with human DDOST associations

				Human Disease	Mouse Models
				congenital disorder of glycosylation Ir IDs congenital disorder of glycosylation Ir DOID:0080569 OMIM:614507 ORDO:300536

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

2
Targeted

4
Genomic Mutations

3 involving Ddost
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

98
cDNA Data

11
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddost

ZFIN ddost

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All Sequences

47
RefSeq

2
UniProt

3
CCDS

CCDS18824.1

Ensembl

ENSMUSG00000028757 (Evidence)
NCBI Gene

13200

			Length	Strain/Species	Flank
genomic	13200	NCBI Gene Model \| MGI Sequence Detail	7882	C57BL/6J	± kb
transcript	NM_007838	RefSeq \| MGI Sequence Detail	2120	C57BL/6
polypeptide	O54734	UniProt \| EBI \| MGI Sequence Detail	441	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006352 dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

(term hierarchy)
InterPro Domains

IPR005013 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit
GlyGen

O54734 1 site, 1 O-linked glycan (1 site)

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All nucleic 11

cDNA 11

Microarray probesets 3

Summaries

All 44

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 15
Earliest

J:44254 Yamagata T, et al., Genome organization of human 48-kDa oligosaccharyltransferase (DDOST). Genomics. 1997 Nov 1;45(3):535-40
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ddost:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39847	Chr4:138032017-138032026 (+)	-27 bp
Tssr39848	Chr4:138032034-138032054 (+)	-5 bp
Tssr39849	Chr4:138032093-138032144 (+)	70 bp
Tssr39850	Chr4:138032146-138032203 (+)	126 bp
Tssr39851	Chr4:138039176-138039203 (+)	7,141 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24