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Psmb5 Gene Detail
Summary
  • Symbol
    Psmb5
  • Name
    proteasome (prosome, macropain) subunit, beta type 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194513
    NCBI Gene: 19173
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54851577-54855452 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 27.86 cM, cytoband C2-D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    176 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194513
 protein coding gene Chr14:54851576-54855479 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021316
 protein coding gene Chr14:48576860-48580789 (-)
A/J MGP_AJ_G0021275
 protein coding gene Chr14:47626363-47630114 (-)
AKR/J MGP_AKRJ_G0021251
 protein coding gene Chr14:49343824-49354205 (-)
BALB/cJ MGP_BALBcJ_G0021279
 protein coding gene Chr14:47601270-47605207 (-)
C3H/HeJ MGP_C3HHeJ_G0021059
 protein coding gene Chr14:49042916-49047383 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0019262
 protein coding gene Chr14:46041990-46046011 (-)
CAST/EiJ MGP_CASTEiJ_G0020578
 protein coding gene Chr14:45282991-45286880 (-)
CBA/J MGP_CBAJ_G0021026
 protein coding gene Chr14:52552576-52556465 (-)
DBA/2J MGP_DBA2J_G0021147
 protein coding gene Chr14:47366533-47370304 (-)
FVB/NJ MGP_FVBNJ_G0021129
 protein coding gene Chr14:46819910-46824155 (-)
LP/J MGP_LPJ_G0021221
 protein coding gene Chr14:49582577-49586466 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021153
 protein coding gene Chr14:51974124-51978013 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021744
 protein coding gene Chr14:48538085-48541974 (-)
PWK/PhJ MGP_PWKPhJ_G0020324
 protein coding gene Chr14:43896318-43900281 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020152
 protein coding gene Chr14:44520092-44523977 (-)
WSB/EiJ MGP_WSBEiJ_G0020631
 protein coding gene Chr14:48825356-48829323 (-)



Homology
more
  • Human Ortholog
    PSMB5, proteasome 20S subunit beta 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMB5, proteasome 20S subunit beta 5
  • Synonyms
    LMPX, MB1
  • Links
    NCBI Gene ID: 5693
    neXtProt AC: NX_P28074
    UniProt: P28074

  • Chr Location
    14q11.2; chr14:23016543-23035230 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Psmb5
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    19 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    143
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19173 NCBI Gene Model | MGI Sequence Detail 3876 C57BL/6J ±  kb
transcript NM_011186 RefSeq | MGI Sequence Detail 871 B10.A-H2  
polypeptide O55234 UniProt | EBI | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 145
    Genomic 1
    cDNA 143
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 6
  • Earliest
    J:44713 Kohda K, et al., Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit. Immunogenetics. 1997;47(1):77-87
  • Latest
    J:343081 Zhang R, et al., Lipid-anchored proteasomes control membrane protein homeostasis. Sci Adv. 2023 Dec;9(48):eadj4605
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory