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Crx Gene Detail
Summary
  • Symbol
    Crx
  • Name
    cone-rod homeobox
  • Synonyms
    Crx1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194883
    NCBI Gene: 12951
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:15599872-15613880 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 8.60 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    388 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194883
 protein coding gene Chr7:15599872-15613893 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031691
 protein coding gene Chr7:13492490-13506340 (-)
A/J MGP_AJ_G0031663
 protein coding gene Chr7:13317895-13332552 (-)
AKR/J MGP_AKRJ_G0031588
 protein coding gene Chr7:13610352-13628093 (-)
BALB/cJ MGP_BALBcJ_G0031670
 protein coding gene Chr7:13408972-13422972 (-)
C3H/HeJ MGP_C3HHeJ_G0031392
 protein coding gene Chr7:13782293-13796483 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032136
 protein coding gene Chr7:14243705-14258217 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029215
 protein coding gene Chr7:14884252-14899112 (-)
CAST/EiJ MGP_CASTEiJ_G0030743
 protein coding gene Chr7:10553156-10569675 (-)
CBA/J MGP_CBAJ_G0031351
 protein coding gene Chr7:14665367-14684881 (-)
DBA/2J MGP_DBA2J_G0031507
 protein coding gene Chr7:13194060-13212463 (-)
FVB/NJ MGP_FVBNJ_G0031463
 protein coding gene Chr7:13086434-13102252 (-)
LP/J MGP_LPJ_G0031592
 protein coding gene Chr7:13768613-13789076 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031498
 protein coding gene Chr7:14651248-14667576 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032165
 protein coding gene Chr7:13380401-13394506 (-)
PWK/PhJ MGP_PWKPhJ_G0030467
 protein coding gene Chr7:10714173-10729100 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030295
 protein coding gene Chr7:8305418-8321330 (-)
WSB/EiJ MGP_WSBEiJ_G0030840
 protein coding gene Chr7:13425212-13442667 (-)



Homology
more
  • Human Ortholog
    CRX, cone-rod homeobox
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRX, cone-rod homeobox
  • Synonyms
    CORD2, CRD, LCA7, OTX3
  • Links
    NCBI Gene ID: 1406
    neXtProt AC: NX_O43186
    UniProt: O43186

  • Chr Location
    19q13.33; chr19:47819779-47843330 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Crx mouse models; 2 with human CRX associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 10 alleles in 11 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit a lack of photoreceptor outer segments and rod and cone activity, reduced expression of several photoreceptor- and pineal-specific genes, and altered circadian behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1021
  • Tissues
    192
  • cDNA Data
    83
  • Literature Summary
    90
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12951 NCBI Gene Model | MGI Sequence Detail 14009 C57BL/6J ±  kb
    transcript NM_007770 RefSeq | MGI Sequence Detail 2931 Not Specified  
    polypeptide O54751 UniProt | EBI | MGI Sequence Detail 299 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      Genomic 3
      cDNA 84
      Primer pair 9
      Other 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 173
      Developmental Gene Expression 90
      Diseases 4
      Gene Ontology 13
      Phenotypes 45
    • Earliest
      J:44380 Kanai A, et al., Heterogeneity and tissue-specific expression of eukaryotic transcription factor S-II-related protein mRNA. J Biochem. 1991 May;109(5):674-7
    • Latest
      J:355222 Nord C, et al., Reduced mTORC1-signaling in progenitor cells leads to retinal lamination deficits. Dev Dyn. 2024 Oct;253(10):922-939
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory