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Evl Gene Detail
Summary
  • Symbol
    Evl
  • Name
    Ena-vasodilator stimulated phosphoprotein
  • Synonyms
    b2b2600Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194884
    NCBI Gene: 14026
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:108520979-108654775 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 59.46 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3267 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194884
 protein coding gene Chr12:108520942-108654775 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020106
 protein coding gene Chr12:110694131-110830095 (+)
A/J MGP_AJ_G0020060
 protein coding gene Chr12:106489845-106621019 (+)
AKR/J MGP_AKRJ_G0020036
 protein coding gene Chr12:109580173-109709854 (+)
BALB/cJ MGP_BALBcJ_G0020046
 protein coding gene Chr12:106900753-107038294 (+)
C3H/HeJ MGP_C3HHeJ_G0019848
 protein coding gene Chr12:110023774-110155208 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020491
 protein coding gene Chr12:114095754-114235785 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018103
 protein coding gene Chr12:103024009-103148632 (+)
CAST/EiJ MGP_CASTEiJ_G0019390
 protein coding gene Chr12:104963658-105099654 (+)
CBA/J MGP_CBAJ_G0019815
 protein coding gene Chr12:118631754-118777939 (+)
DBA/2J MGP_DBA2J_G0019932
 protein coding gene Chr12:106030741-106161415 (+)
FVB/NJ MGP_FVBNJ_G0019917
 protein coding gene Chr12:104813318-104942980 (+)
LP/J MGP_LPJ_G0020007
 protein coding gene Chr12:110562771-110698649 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019955
 protein coding gene Chr12:121815340-121948922 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020520
 protein coding gene Chr12:109062146-109194516 (+)
PWK/PhJ MGP_PWKPhJ_G0019149
 protein coding gene Chr12:100640957-100772787 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018953
 protein coding gene Chr12:103260298-103395324 (+)
WSB/EiJ MGP_WSBEiJ_G0019447
 protein coding gene Chr12:109995394-110129109 (+)



Homology
more
  • Human Ortholog
    EVL, Enah/Vasp-like
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EVL, Enah/Vasp-like
  • Synonyms
    RNB6
  • Links
    NCBI Gene ID: 51466
    neXtProt AC: NX_Q9UI08
    UniProt: Q9UI08

  • Chr Location
    14q32.2; chr14:99971422-100144236 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotypes from multigenic genotypes
    9 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable with no apparent defects in gross morphology or histology. Mice homozygous for a different knock-out allele are viable and fertile but display defects in monocyte migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    73
  • cDNA Data
    100
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021262 Ensembl Gene Model | MGI Sequence Detail 133797 C57BL/6J ±  kb
    transcript ENSMUST00000223109 Ensembl | MGI Sequence Detail 1487 Not Applicable  
    polypeptide ENSMUSP00000152364 Ensembl | MGI Sequence Detail 426 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      cDNA 101

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2144857, MGI:5560789
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 10
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:44192 Gertler FB, et al., Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell. 1996 Oct 18;87(2):227-39
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory