Nfkbie MGI Mouse Gene Detail - MGI:1194908 - nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon

Symbol

Nfkbie
Name

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon

Feature Type

protein coding gene
IDs

MGI:1194908
NCBI Gene: 18037
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr17:45866629-45874095 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 22.58 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

232 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1194908	protein coding gene	Chr17:45866626-45874095 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023791	protein coding gene	Chr17:46574772-46582226 (+)
A/J	MGP_AJ_G0023749	protein coding gene	Chr17:45457414-45464909 (+)
AKR/J	MGP_AKRJ_G0023720	protein coding gene	Chr17:45770582-45778088 (+)
BALB/cJ	MGP_BALBcJ_G0023753	protein coding gene	Chr17:45347211-45354715 (+)
C3H/HeJ	MGP_C3HHeJ_G0023517	protein coding gene	Chr17:46483112-46490610 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024196	protein coding gene	Chr17:48584579-48592424 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021646	protein coding gene	Chr17:42254469-42261998 (+)
CAST/EiJ	MGP_CASTEiJ_G0022998	protein coding gene	Chr17:46577508-46587806 (+)
CBA/J	MGP_CBAJ_G0023493	protein coding gene	Chr17:50311065-50318524 (+)
DBA/2J	MGP_DBA2J_G0023619	protein coding gene	Chr17:44248444-44255938 (+)
FVB/NJ	MGP_FVBNJ_G0023586	protein coding gene	Chr17:43824978-43832487 (+)
LP/J	MGP_LPJ_G0023700	protein coding gene	Chr17:47220868-47228361 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023615	protein coding gene	Chr17:49878346-49885841 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024241	protein coding gene	Chr17:46136347-46143860 (+)
PWK/PhJ	MGP_PWKPhJ_G0022743	protein coding gene	Chr17:43556157-43563664 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022558	protein coding gene	Chr17:43000096-43007500 (+)
WSB/EiJ	MGP_WSBEiJ_G0023063	protein coding gene	Chr17:46654177-46662698 (+)

Human Ortholog

NFKBIE, NFKB inhibitor epsilon

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NFKBIE, NFKB inhibitor epsilon
Synonyms

IKBE
Links

HGNC:7799

NCBI Gene ID: 4794

neXtProt AC: NX_O00221

UniProt: O00221
Chr Location

6p21.1; chr6:44258166-44265788 (-) GRCh38

MGI Vertebrate Homology

Nfkbie stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NFKBIE
Gene Tree

Nfkbie

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
7 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

4
Gene trapped

1
Targeted

5
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions of this gene display an essentially normal phenotype.

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All GO Annotations

10
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

56
cDNA Data

27
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nfkbie

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All Sequences

41
RefSeq

4
UniProt

3
CCDS

CCDS28811.1, CCDS89104.1

Ensembl

ENSMUSG00000023947 (Evidence)
NCBI Gene

18037

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023947	Ensembl Gene Model \| MGI Sequence Detail	7467	C57BL/6J	± kb
transcript	ENSMUST00000233929	Ensembl \| MGI Sequence Detail	2356	Not Applicable
polypeptide	ENSMUSP00000156580	Ensembl \| MGI Sequence Detail	371	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003295 NF-kappa-B inhibitor epsilon

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR051070 NF-kappa-B Inhibitor
GlyGen

O54910 1 site, 1 O-linked glycan (1 site)

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All nucleic 28

cDNA 28

Microarray probesets 5

Summaries

All 53

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 15
Earliest

J:45073 Simeonidis S, et al., Cloning and functional characterization of mouse IkappaBepsilon. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14372-7
Latest

J:323815 Cheng QJ, et al., NF-kappaB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages. Science. 2021 Jun 18;372(6548):1349-1353

TSS for Nfkbie:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144787	Chr17:45866562-45866599 (+)	-48 bp
Tssr144788	Chr17:45866619-45866640 (+)	1 bp
Tssr144789	Chr17:45866653-45866672 (+)	34 bp
Tssr144790	Chr17:45866720-45866725 (+)	94 bp
Tssr144791	Chr17:45866731-45866743 (+)	108 bp
Tssr144792	Chr17:45866804-45866826 (+)	186 bp
Tssr144793	Chr17:45867185-45867196 (+)	562 bp
Tssr144794	Chr17:45871930-45871934 (+)	5,303 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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