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Pla2g4a Gene Detail
Summary
  • Symbol
    Pla2g4a
  • Name
    phospholipase A2, group IVA (cytosolic, calcium-dependent)
  • Synonyms
    cPLA2, cPLA2alpha, cytosolic phospholipase A2, cytosolic PLA2, Pla2g4, Type IV PLA2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195256
    NCBI Gene: 18783
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:149705369-149837041 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 63.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4713 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195256
 protein coding gene Chr1:149705369-149837041 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016571
 protein coding gene Chr1:154451590-154588898 (-)
A/J MGP_AJ_G0016554
 protein coding gene Chr1:148171243-148306737 (-)
AKR/J MGP_AKRJ_G0016519
 protein coding gene Chr1:152724411-152850048 (-)
BALB/cJ MGP_BALBcJ_G0016514
 protein coding gene Chr1:148768640-148901891 (-)
C3H/HeJ MGP_C3HHeJ_G0016339
 protein coding gene Chr1:152935342-153073216 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016975
 protein coding gene Chr1:159802116-159936425 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014684
 protein coding gene Chr1:140547877-140678109 (-)
CAST/EiJ MGP_CASTEiJ_G0015918
 protein coding gene Chr1:152352756-152495323 (-)
CBA/J MGP_CBAJ_G0016313
 protein coding gene Chr1:165454145-165608346 (-)
DBA/2J MGP_DBA2J_G0016419
 protein coding gene Chr1:147268910-147404589 (-)
FVB/NJ MGP_FVBNJ_G0016417
 protein coding gene Chr1:145720261-145850309 (-)
LP/J MGP_LPJ_G0016490
 protein coding gene Chr1:155442082-155588203 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016443
 protein coding gene Chr1:173117478-173271474 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017011
 protein coding gene Chr1:152546343-152684666 (-)
PWK/PhJ MGP_PWKPhJ_G0015704
 protein coding gene Chr1:146199073-146332887 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015491
 protein coding gene Chr1:151193296-151330793 (-)
WSB/EiJ MGP_WSBEiJ_G0015981
 protein coding gene Chr1:152646582-152791127 (-)



Homology
more
  • Human Ortholog
    PLA2G4A, phospholipase A2 group IVA
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLA2G4A, phospholipase A2 group IVA
  • Synonyms
    cPLA2, cPLA2-alpha, GURDP, PLA2G4
  • Links
    NCBI Gene ID: 5321
    neXtProt AC: NX_P47712
    UniProt: P47712

  • Chr Location
    1q31.1; chr1:186828949-186988981 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 2 alleles in 7 genetic backgrounds
    5 phenotypes from multigenic genotypes
    103 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygouse for disruptions in this gene display reduced allergic and autoimmune reactions. They also display an increased incidence of insulin and reduced female reproductive performance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    86
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1014
  • Tissues
    159
  • cDNA Data
    44
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18783 NCBI Gene Model | MGI Sequence Detail 131673 C57BL/6J ±  kb
    transcript NM_008869 RefSeq | MGI Sequence Detail 2869 ZRU/MplStud  
    polypeptide P47713 UniProt | EBI | MGI Sequence Detail 748 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 2
      cDNA 44
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 168
      Developmental Gene Expression 6
      Gene Ontology 15
      Phenotypes 103
    • Earliest
      J:28587 Clark MA, et al., Cloning of a phospholipase A2-activating protein. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5418-22
    • Latest
      J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory