Slc22a12 MGI Mouse Gene Detail - MGI:1195269 - solute carrier family 22 (organic anion/cation transporter), member 12

Symbol

Slc22a12
Name

solute carrier family 22 (organic anion/cation transporter), member 12
Synonyms

Rst, URAT1

Feature Type

protein coding gene
IDs

MGI:1195269
NCBI Gene: 20521
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr19:6585875-6593062 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.05 cM, cytoband A
Mapping Data

2 experiments

SNPs within 2kb

73 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1195269	protein coding gene	Chr19:6585875-6593100 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024765	protein coding gene	Chr19:3604925-3612099 (-)
A/J	MGP_AJ_G0024731	protein coding gene	Chr19:3403010-3410184 (-)
AKR/J	MGP_AKRJ_G0024704	protein coding gene	Chr19:3503333-3510507 (-)
BALB/cJ	MGP_BALBcJ_G0024731	protein coding gene	Chr19:3401971-3409139 (-)
C3H/HeJ	MGP_C3HHeJ_G0024499	protein coding gene	Chr19:3524538-3531712 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025177	protein coding gene	Chr19:3663133-3670307 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022611	protein coding gene	Chr19:3329359-3336692 (-)
CAST/EiJ	MGP_CASTEiJ_G0023971	protein coding gene	Chr19:3546776-3553940 (-)
CBA/J	MGP_CBAJ_G0024471	protein coding gene	Chr19:3847599-3854810 (-)
DBA/2J	MGP_DBA2J_G0024598	protein coding gene	Chr19:3389457-3396964 (-)
FVB/NJ	MGP_FVBNJ_G0024564	protein coding gene	Chr19:3408672-3415841 (-)
LP/J	MGP_LPJ_G0024684	protein coding gene	Chr19:3564091-3571213 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024593	protein coding gene	Chr19:3648536-3655710 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025225	protein coding gene	Chr19:3529203-3536377 (-)
PWK/PhJ	MGP_PWKPhJ_G0023717	protein coding gene	Chr19:3427646-3435196 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023522	protein coding gene	Chr19:3485044-3492207 (-)
WSB/EiJ	MGP_WSBEiJ_G0024033	protein coding gene	Chr19:3545529-3552693 (-)

Human Ortholog

SLC22A12, solute carrier family 22 member 12

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC22A12, solute carrier family 22 member 12
Synonyms

hURAT1, OAT4L, RST, UAT, URAT1
Links

HGNC:17989

NCBI Gene ID: 116085

neXtProt AC: NX_Q96S37

UniProt: Q96S37
Chr Location

11q13.1; chr11:64590641-64602353 (+) GRCh38

MGI Vertebrate Homology

Slc22a12 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SLC22A12
Gene Tree

Slc22a12

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Phenotype Summary

14 phenotypes from 2 alleles in 3 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Targeted

5
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased urinary urate levels and altered urine and plasma metabolite composition.

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

900
Tissues

111
cDNA Data

67
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

3
CCDS

CCDS29505.1

Ensembl

ENSMUSG00000061742 (Evidence)
NCBI Gene

20521

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061742	Ensembl Gene Model \| MGI Sequence Detail	7188	C57BL/6J	± kb
transcript	ENSMUST00000113451	Ensembl \| MGI Sequence Detail	2226	Not Applicable
polypeptide	ENSMUSP00000109078	Ensembl \| MGI Sequence Detail	553	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014983 solute carrier family 22 member 12

(term hierarchy)
InterPro Domains

IPR005828 Major facilitator, sugar transporter-like

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily
GlyGen

Q8CFZ5 1 site

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All nucleic 70

cDNA 67

Primer pair 3

Microarray probesets 4

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MGI:2147622

Summaries

All 44

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 10
Earliest

J:44355 Mori K, et al., Kidney-specific expression of a novel mouse organic cation transporter-like protein. FEBS Lett. 1997 Nov 17;417(3):371-4
Latest

J:338261 Toyoda Y, et al., Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations. Pflugers Arch. 2023 Apr;475(4):489-504

TSS for Slc22a12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157865	Chr19:6593112-6593118 (-)	-53 bp
Tssr157864	Chr19:6593094-6593105 (-)	-38 bp
Tssr157863	Chr19:6593049-6593069 (-)	3 bp
Tssr157862	Chr19:6593019-6593044 (-)	30 bp
Tssr157861	Chr19:6591695-6591700 (-)	1,364 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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