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Aqp8 Gene Detail
Summary
  • Symbol
    Aqp8
  • Name
    aquaporin 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195271
    NCBI Gene: 11833
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:123061517-123067226 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 67.42 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    217 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195271
 protein coding gene Chr7:123061514-123067227 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032963
 protein coding gene Chr7:127608680-127614393 (+)
A/J MGP_AJ_G0032946
 protein coding gene Chr7:124295394-124301107 (+)
AKR/J MGP_AKRJ_G0032878
 protein coding gene Chr7:127455371-127461084 (+)
BALB/cJ MGP_BALBcJ_G0032951
 protein coding gene Chr7:123964997-123970710 (+)
C3H/HeJ MGP_C3HHeJ_G0032661
 protein coding gene Chr7:127365073-127370786 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033457
 protein coding gene Chr7:132588262-132593975 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030429
 protein coding gene Chr7:125591009-125596927 (+)
CAST/EiJ MGP_CASTEiJ_G0031989
 protein coding gene Chr7:119176526-119182362 (+)
CBA/J MGP_CBAJ_G0032634
 protein coding gene Chr7:137054788-137060501 (+)
DBA/2J MGP_DBA2J_G0032786
 protein coding gene Chr7:122276504-122282217 (+)
FVB/NJ MGP_FVBNJ_G0032739
 protein coding gene Chr7:122127550-122133263 (+)
LP/J MGP_LPJ_G0032880
 protein coding gene Chr7:129040125-129045838 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032771
 protein coding gene Chr7:138389041-138394754 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033477
 protein coding gene Chr7:126453158-126458871 (+)
PWK/PhJ MGP_PWKPhJ_G0031697
 protein coding gene Chr7:115222101-115227814 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031543
 protein coding gene Chr7:113245786-113251596 (+)
WSB/EiJ MGP_WSBEiJ_G0032102
 protein coding gene Chr7:127374628-127380341 (+)



Homology
more
  • Human Ortholog
    AQP8, aquaporin 8
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AQP8, aquaporin 8
  • Synonyms
    AQP-8
  • Links
    NCBI Gene ID: 343
    neXtProt AC: NX_O94778
    UniProt: O94778

  • Chr Location
    16p12.1; chr16:25215731-25228932 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males homozygous for a null allele are fertile but show enlarged testes and reduced water permeability in testis plasma membranes. Females show increased ovulation, corpora lutea number and fertility, and a decrease in the plasma membrane water permeability and apoptosis rate of granulosa cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    948
  • Tissues
    106
  • cDNA Data
    75
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11833 NCBI Gene Model | MGI Sequence Detail 5710 C57BL/6J ±  kb
    transcript NM_007474 RefSeq | MGI Sequence Detail 1486 ZRU/MplStud  
    polypeptide P56404 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      Genomic 1
      cDNA 75
      Primer pair 9
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141886
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 19
      Gene Ontology 15
      Phenotypes 12
    • Earliest
      J:44349 Ma T, et al., Cloning of a novel water and urea-permeable aquaporin from mouse expressed strongly in colon, placenta, liver, and heart. Biochem Biophys Res Commun. 1997 Nov 17;240(2):324-8
    • Latest
      J:355142 Gomez-Del Arco P, et al., The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024 Oct 4;15(1):8602
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory