Lilra6 Gene Detail

Summary

• Symbol
  Lilra6
• Name
  leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
• Synonyms
  7M1, Pira3

• Feature Type
  protein coding gene
• IDs
  MGI:1195969
  NCBI Gene: 18726
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr7:3911279-3918502 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 2.25 cM
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  373 from dbSNP Build 142
• Strain Annotations
  12

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1195969	protein coding gene	Chr7:3911276-3918569 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031532	protein coding gene	Chr7:692010-698729 (-)
A/J	MGP_AJ_G0031509	protein coding gene	Chr7:758771-766612 (-)
AKR/J	MGP_AKRJ_G0031435	protein coding gene	Chr7:814538-847800 (-)
BALB/cJ	MGP_BALBcJ_G0031514	protein coding gene	Chr7:635594-656505 (-)
C3H/HeJ	MGP_C3HHeJ_G0031236	protein coding gene	Chr7:644317-652066 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031975	protein coding gene	Chr7:692352-765506 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029102	protein coding gene	Chr7:593585-597561 (-)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0031195	protein coding gene	Chr7:811794-826227 (-)
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0031306	protein coding gene	Chr7:587158-760451 (-)
LP/J	no annotation
NOD/ShiLtJ	MGP_NODShiLtJ_G0031345	protein coding gene	Chr7:880903-920696 (-)
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0030154	protein coding gene	Chr7:916233-930239 (-)
WSB/EiJ	no annotation

Homology

• Human Ortholog
  LILRA1, leukocyte immunoglobulin like receptor A1

• Vertebrate Orthologs
  9

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LILRA1, leukocyte immunoglobulin like receptor A1
  
• Synonyms
  CD85I, LIR-6, LIR6
• Links
  HGNC:6602

  NCBI Gene ID: 11024

  neXtProt AC: NX_O75019

  UniProt: O75019

  
  
• Chr Location
  19q13.42; chr19:54593582-54602381 (+)  GRCh38

---

• Human Ortholog
  LILRA2, leukocyte immunoglobulin like receptor A2
  
• Synonyms
  CD85H, ILT1, LIR-7, LIR7
• Links
  HGNC:6603

  NCBI Gene ID: 11027

  neXtProt AC: NX_Q8N149

  UniProt: Q8N149

  
  
• Chr Location
  19q13.42; chr19:54572920-54590287 (+)  GRCh38

---

• Human Ortholog
  LILRA3, leukocyte immunoglobulin like receptor A3
  
• Synonyms
  CD85E, HM31, HM43, ILT-6, ILT6, LIR-4, LIR4
• Links
  HGNC:6604

  NCBI Gene ID: 11026

  neXtProt AC: NX_Q8N6C8

  UniProt: Q8N6C8

  
  
• Chr Location
  19q13.4

---

• Human Ortholog
  LILRA4, leukocyte immunoglobulin like receptor A4
  
• Synonyms
  CD85g, ILT7
• Links
  HGNC:15503

  NCBI Gene ID: 23547

  neXtProt AC: NX_P59901

  UniProt: P59901

  
  
• Chr Location
  19q13.42; chr19:54333185-54339162 (-)  GRCh38

---

• Human Ortholog
  LILRA6, leukocyte immunoglobulin like receptor A6
  
• Synonyms
  CD85b, ILT5, ILT-8, ILT8, LILRB3, LILRB6
• Links
  HGNC:15495

  NCBI Gene ID: 79168

  UniProt: Q6PI73

  
  
• Chr Location
  19q13.42; chr19:54236590-54242790 (-)  GRCh38

---

• Human Ortholog
  LILRB3, leukocyte immunoglobulin like receptor B3
  
• Synonyms
  CD85A, HL9, ILT-5, ILT5, LILRA6, LIR-3, LIR3, PIR-B, PIRB
• Links
  HGNC:6607

  NCBI Gene ID: 11025

  neXtProt AC: NX_O75022

  UniProt: O75022

  
  
• Chr Location
  19q13.42; chr19:54216278-54223506 (-)  GRCh38

---

• MGI Vertebrate Homology
  Lilra6 stringent orthology
  6 human;1 mouse;3 rat
  
• HCOP
  vertebrate homology predictions: LILRA1, LILRA2, LILRA3, LILRA4, LILRA6, LILRB3
• Gene Tree
  Lilra6
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  3
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  35 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  10
• GO References
  2

Expression

• Assay Results
  712
• Tissues
  1
• cDNA Data
  6
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  45
• RefSeq
  11
• UniProt
  5
• CCDS
  CCDS20728.1

• Ensembl
  ENSMUSG00000030427 (Evidence)
• NCBI Gene
  18726

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000030427	Ensembl Gene Model | MGI Sequence Detail	7224	C57BL/6J
transcript	ENSMUST00000038176	Ensembl | MGI Sequence Detail	2103	Not Applicable
polypeptide	ENSMUSP00000042636	Ensembl | MGI Sequence Detail	663	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• InterPro Domains
  IPR013151 Immunoglobulin
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR050412 Immunoglobulin-like Receptors in Immune Regulation
  IPR003599 Immunoglobulin subtype
  IPR003598 Immunoglobulin subtype 2

Molecular
Reagents

• All nucleic 8

  cDNA 7

  Primer pair 1

  
  

  Microarray probesets 2

References

• Summaries
  All 19

  Developmental Gene Expression 1

  Gene Ontology 2

  Phenotypes 2
• Earliest
  J:44191 Kubagawa H, et al., A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells [see comments]. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5261-6
• Latest
  J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25