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Tcaim Gene Detail
Summary
  • Symbol
    Tcaim
  • Name
    T cell activation inhibitor, mitochondrial
  • Synonyms
    D9Ertd402e, LOC382117
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196217
    NCBI Gene: 382117
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:122634604-122665399 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 73.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    682 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196217
 protein coding gene Chr9:122634586-122665399 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035462
 protein coding gene Chr9:125806299-125837006 (+)
A/J MGP_AJ_G0035443
 protein coding gene Chr9:120993334-121023944 (+)
AKR/J MGP_AKRJ_G0035376
 protein coding gene Chr9:124246295-124276863 (+)
BALB/cJ MGP_BALBcJ_G0035439
 protein coding gene Chr9:120915133-120945293 (+)
C3H/HeJ MGP_C3HHeJ_G0035146
 protein coding gene Chr9:124681280-124717308 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035962
 protein coding gene Chr9:129264917-129310351 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032844
 protein coding gene Chr9:118121563-118158450 (+)
CAST/EiJ MGP_CASTEiJ_G0034451
 protein coding gene Chr9:124708363-124744455 (+)
CBA/J MGP_CBAJ_G0035114
 protein coding gene Chr9:133990931-134023143 (+)
DBA/2J MGP_DBA2J_G0035273
 protein coding gene Chr9:120441802-120473370 (+)
FVB/NJ MGP_FVBNJ_G0035220
 protein coding gene Chr9:119360876-119392367 (+)
LP/J MGP_LPJ_G0035352
 protein coding gene Chr9:126146801-126178083 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035261
 protein coding gene Chr9:134851709-134886291 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035981
 protein coding gene Chr9:124700906-124731531 (+)
PWK/PhJ MGP_PWKPhJ_G0034155
 protein coding gene Chr9:120897126-120929040 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033992
 protein coding gene Chr9:124784373-124820485 (+)
WSB/EiJ MGP_WSBEiJ_G0034571
 protein coding gene Chr9:124545055-124577374 (+)



Homology
more
  • Human Ortholog
    TCAIM, T cell activation inhibitor, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCAIM, T cell activation inhibitor, mitochondrial
  • Synonyms
    C3orf23, TOAG-1, TOAG1
  • Links
    NCBI Gene ID: 285343
    neXtProt AC: NX_Q8N3R3
    UniProt: Q8N3R3

  • Chr Location
    3p21.31; chr3:44338119-44409451 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    36
  • cDNA Data
    31
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046603 Ensembl Gene Model | MGI Sequence Detail 30796 C57BL/6J ±  kb
    transcript ENSMUST00000052740 Ensembl | MGI Sequence Detail 3049 Not Applicable  
    polypeptide ENSMUSP00000049759 Ensembl | MGI Sequence Detail 509 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000059930 T-cell activation inhibitor, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR028031 Domain of unknown function DUF4460
      IPR027989 Domain of unknown function DUF4461
      IPR027986 T-cell activation inhibitor, mitochondrial
    • GlyGen
      Q66JZ4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 31
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2685975
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory