Cdk8 MGI Mouse Gene Detail - MGI:1196224 - cyclin dependent kinase 8

Symbol

Cdk8
Name

cyclin dependent kinase 8
Synonyms

MGC:37111

Feature Type

protein coding gene
IDs

MGI:1196224
NCBI Gene: 264064
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr5:146168040-146239684 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 85.19 cM
Mapping Data

1 experiment

SNPs within 2kb

1906 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196224	protein coding gene	Chr5:146167432-146239684 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030375	protein coding gene	Chr5:151794415-151867814 (+)
A/J	MGP_AJ_G0030348	protein coding gene	Chr5:145380672-145456347 (+)
AKR/J	MGP_AKRJ_G0030275	protein coding gene	Chr5:149804895-149883046 (+)
BALB/cJ	MGP_BALBcJ_G0030357	protein coding gene	Chr5:146589557-146664183 (+)
C3H/HeJ	MGP_C3HHeJ_G0030071	protein coding gene	Chr5:150757517-150835524 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030812	protein coding gene	Chr5:157370045-157444030 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028025	protein coding gene	Chr5:139799439-139873362 (+)
CAST/EiJ	MGP_CASTEiJ_G0029473	protein coding gene	Chr5:150263693-150340219 (+)
CBA/J	MGP_CBAJ_G0030049	protein coding gene	Chr5:163899310-163980845 (+)
DBA/2J	MGP_DBA2J_G0030193	protein coding gene	Chr5:145042042-145116118 (+)
FVB/NJ	MGP_FVBNJ_G0030147	protein coding gene	Chr5:144254449-144325617 (+)
LP/J	MGP_LPJ_G0030280	protein coding gene	Chr5:152474812-152547164 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030183	protein coding gene	Chr5:166261513-166335882 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030842	protein coding gene	Chr5:149723529-149795629 (+)
PWK/PhJ	MGP_PWKPhJ_G0029187	protein coding gene	Chr5:144129037-144202795 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029023	protein coding gene	Chr5:146973902-147054865 (+)
WSB/EiJ	MGP_WSBEiJ_G0029550	protein coding gene	Chr5:150527802-150607276 (+)

Human Ortholog

CDK8, cyclin dependent kinase 8

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDK8, cyclin dependent kinase 8
Synonyms

IDDHBA, K35
Links

HGNC:1779

NCBI Gene ID: 1024

neXtProt AC: NX_P49336

UniProt: P49336
Chr Location

13q12.13; chr13:26254104-26420982 (+) GRCh38

MGI Vertebrate Homology

Cdk8 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: CDK8
Gene Tree

Cdk8

Diseases

1 with human CDK8 associations

				Human Disease	Mouse Models
				dilated cardiomyopathy IDs dilated cardiomyopathy DOID:12930 EFO:0000407 ICD10CM:I42.0 KEGG:05414 MESH:D002311 NCI:C84673 OMIM:PS115200 ORDO:217604 UMLS_CUI:C0007193

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

19 phenotypes from 3 alleles in 4 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

1
Gene trapped

23
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene-trapped allele die prior to implantation exhibiting fragmented blastomeres and failure to undergo compaction.

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All GO Annotations

28
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

6
cDNA Data

93
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDK8

Xenbase cdk8

ZFIN cdk8

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All Sequences

72
RefSeq

18
UniProt

6
CCDS

CCDS19869.1, CCDS90018.1

Ensembl

ENSMUSG00000029635 (Evidence)
NCBI Gene

264064

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029635	Ensembl Gene Model \| MGI Sequence Detail	71645	C57BL/6J	± kb
transcript	ENSMUST00000031640	Ensembl \| MGI Sequence Detail	2973	Not Applicable
polypeptide	ENSMUSP00000031640	Ensembl \| MGI Sequence Detail	464	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000005266 cyclin-dependent kinase 8

(term hierarchy)
EC

2.7.11.22, 2.7.11.23
InterPro Domains

IPR050108 Cyclin-dependent kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q8R3L8 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 95

cDNA 93

Primer pair 2

Microarray probesets 3

Summaries

All 70

Developmental Gene Expression 6

Gene Ontology 14

Phenotypes 26
Earliest

J:45218 Ahuja HS, et al., Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death. Dev Genet. 1997;21(4):258-67
Latest

J:347774 Kolonay DW, et al., Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Front Cell Dev Biol. 2024;12:1331563

TSS for Cdk8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49768	Chr5:146167973-146167996 (+)	-55 bp
Tssr49769	Chr5:146168021-146168084 (+)	13 bp
Tssr49770	Chr5:146197794-146197838 (+)	29,776 bp
Tssr49771	Chr5:146197858-146197898 (+)	29,838 bp
Tssr49772	Chr5:146197955-146197987 (+)	29,931 bp
Tssr49773	Chr5:146198049-146198063 (+)	30,016 bp
Tssr49774	Chr5:146198065-146198105 (+)	30,045 bp
Tssr49775	Chr5:146198109-146198137 (+)	30,083 bp
Tssr49776	Chr5:146198143-146198154 (+)	30,109 bp
Tssr49777	Chr5:146229438-146229459 (+)	61,409 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24